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3,4 Dichloroisocoumarin

Name: 3,4 Dichloroisocoumarin
Brand: TargetMol
SKU: T8677
Price: 378 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T8677Cas号 51050-59-0 一键复制产品信息纯度: 97.94%

很棒

3,4 Dichloroisocoumarin 是一种颗粒酶、组织蛋白酶 G 和中性粒细胞弹性蛋白酶抑制剂

3,4 Dichloroisocoumarin

一键复制产品信息

很棒

纯度: 97.94%

货号 T8677Cas号 51050-59-0

3,4 Dichloroisocoumarin 是一种颗粒酶、组织蛋白酶 G 和中性粒细胞弹性蛋白酶抑制剂

规格	价格	库存
1 mg	¥ 378	现货
5 mg	¥ 913	现货
10 mg	¥ 1,580	现货
25 mg	¥ 2,670	现货
50 mg	¥ 3,890	现货
100 mg	¥ 5,570	现货
1 mL x 10 mM (in DMSO)	¥ 848	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.94%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

3,4 Dichloroisocoumarin AI Summary

3,4 Dichloroisocoumarin shows a broad range of bioactivities, demonstrating its potential across various therapeutic areas. It functions as an inhibitor of elastase enzymes, including human leukocyte elastase with an IC50 of 100.0 nM, rat leukocyte elastase with an IC50 of 700.0 nM, and pancreatitic porcine elastase with an IC50 of 800.0 nM. Additionally, it inhibits various blood coagulation factors like bovine thrombin, human thrombin, and porcine factor IXa with differing binding affinities. Its enzymatic inhibition extends to targets such as prodrug hydrolase, recombinant CatA, human PBMC extract prodrug hydrolase, and cathepsin G, exhibiting IC50 values from 500.0 nM to 93000.0 nM. The compound also impedes Toxoplasma gondii 2F1 invasion in HFF cells with an IC50 of 12500.0 nM and shows antiplasmodial activity against Plasmodium falciparum W2 with an IC50 of 15848.93 nM. Further, it disrupts various cellular pathways including NFkB signaling, mitochondrial function, and protein splicing, and targets enzymes such as Cytochrome P450 and ALDH1A1. 3,4 Dichloroisocoumarin exhibits antiviral potential by inhibiting Lassa Virus and Marburg Virus entry into cells and is also noted for its reversible inhibition of Escherichia coli rhomboid GlpG. Thus, 3,4 Dichloroisocoumarin presents significant bioactivity across multiple biological targets, indicating its versatility and potential for therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor

化学信息

分子量	215.03
分子式	C₉H₄Cl₂O₂
CAS No.	51050-59-0
Smiles	Clc1oc(=O)c2ccccc2c1Cl
密度	1.53 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 150 mg/mL (697.58 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6505 mL	23.2526 mL	46.5051 mL	232.5257 mL
5 mM	0.9301 mL	4.6505 mL	9.3010 mL	46.5051 mL
10 mM	0.4651 mL	2.3253 mL	4.6505 mL	23.2526 mL
20 mM	0.2325 mL	1.1626 mL	2.3253 mL	11.6263 mL
50 mM	0.0930 mL	0.4651 mL	0.9301 mL	4.6505 mL
100 mM	0.0465 mL	0.2325 mL	0.4651 mL	2.3253 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。