5-AIQ

Name: 5-AIQ
Brand: TargetMol
SKU: T50044
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 95.95%

货号 T50044Cas号 93117-08-9

5-AIQ 是小牛胸腺 PARP1 的抑制剂。

5-AIQ

一键复制产品信息

很棒

纯度: 95.95%

货号 T50044Cas号 93117-08-9

5-AIQ 是小牛胸腺 PARP1 的抑制剂。

规格	价格	库存	数量
50 mg	¥ 139	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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COA HNMR LCMS 产品操作手册

产品介绍

5-AIQ AI Summary

5-AIQ is a potent inhibitor of poly (ADP-ribose) polymerase (PARP), demonstrating significant activity across various sources. It inhibits human recombinant PARP1 with an IC50 of 1800.0 nM, calf thymus PARP1 with an IC50 of 240.0 nM, full-length human PARP-1 with an IC50 of 940.0 nM, and recombinant full-length mouse PARP-2 with an IC50 of 1050.0 nM. The compound also exhibits inhibitory activity against enzymes such as RecQ-Like DNA Helicase 1 (RECQ1), Tyrosyl-DNA Phosphodiesterase (TDP1), and Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia, and inhibits the interaction between CBF-beta and RUNX1, which is relevant for Acute Myeloid Leukemia treatment. Furthermore, 5-AIQ shows varying levels of growth inhibition in different human cell lines, including HT-29, LNCAP, FEK4, and MDA-MB-231, and inhibits mouse CT26 cell proliferation by 40% at 1 mM. These characteristics suggest potential therapeutic applications for 5-AIQ in conditions where PARP inhibition and other targeted enzyme interactions are beneficial..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.

化学信息

分子量	160.17
分子式	C₉H₈N₂O
CAS No.	93117-08-9
Smiles	NC1=C2C=CNC(=O)C2=CC=C1
密度	1.287g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (280.95 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2434 mL	31.2168 mL	62.4337 mL	312.1683 mL
5 mM	1.2487 mL	6.2434 mL	12.4867 mL	62.4337 mL
10 mM	0.6243 mL	3.1217 mL	6.2434 mL	31.2168 mL
20 mM	0.3122 mL	1.5608 mL	3.1217 mL	15.6084 mL
50 mM	0.1249 mL	0.6243 mL	1.2487 mL	6.2434 mL
100 mM	0.0624 mL	0.3122 mL	0.6243 mL	3.1217 mL