Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IndiMitecan (LMP776) 是一种具有抗癌活性的拓扑异构酶 I(Top1)抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 987 | 现货 | ||
2 mg | ¥ 1,550 | 现货 | ||
5 mg | ¥ 2,620 | 现货 | ||
10 mg | ¥ 3,930 | 现货 | ||
25 mg | ¥ 6,280 | 现货 | ||
50 mg | ¥ 8,650 | 现货 | ||
100 mg | ¥ 11,600 | 现货 |
产品描述 | IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1]. |
体外活性 | Indimitecan (LMP776) (0-100 μM) demonstrates antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM [1]. Indimitecan shows potent DNA cleavage due to Top1 inhibition [1]. Indimitecan can be substrates for metabolic ketone reductases [1]. Cell Proliferation Assay [1] Cell Line: HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7 Concentration: 0-100 μM Incubation Time: Result: Showed growth inhibition with GI 50 s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM. |
别名 | LMP776 |
分子量 | 459.45 |
分子式 | C25H21N3O6 |
CAS No. | 915360-05-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.7 mg/mL (16.7 mM), when pH is adjusted to 3 with HCl. Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1765 mL | 10.8826 mL | 21.7652 mL | 54.4129 mL |
5 mM | 0.4353 mL | 2.1765 mL | 4.353 mL | 10.8826 mL | |
10 mM | 0.2177 mL | 1.0883 mL | 2.1765 mL | 5.4413 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IndiMitecan 915360-05-3 DNA Damage/DNA Repair Topoisomerase LMP 776 LMP-776 LMP776 Inhibitor inhibitor inhibit