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Vigabatrin

Name: Vigabatrin
Brand: TargetMol
SKU: T0128
Price: 169 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氨己烯酸, Vigabatrine, Sabril

货号 T0128Cas号 60643-86-9 一键复制产品信息纯度: 99.88%

很棒

Vigabatrin (Sabril) 是 γ-氨基丁酸的类似物，是 4-氨基丁酸转氨酶的不可逆抑制剂，负责 γ-氨基丁酸分解代谢。它可用于可卡因依赖的治疗。

Vigabatrin

一键复制产品信息

很棒

纯度: 99.88%

货号 T0128Cas号 60643-86-9

别名 氨己烯酸, Vigabatrine, Sabril

Vigabatrin (Sabril) 是 γ-氨基丁酸的类似物，是 4-氨基丁酸转氨酶的不可逆抑制剂，负责 γ-氨基丁酸分解代谢。它可用于可卡因依赖的治疗。

规格	价格	库存
1 mg	¥ 169	现货
5 mg	¥ 360	现货
10 mg	¥ 640	现货
25 mg	¥ 1,230	现货
50 mg	¥ 2,120	现货
100 mg	¥ 3,810	现货
500 mg	¥ 8,290	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.88%

颜色: 白色至黄色

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Vigabatrin AI Summary

Vigabatrin exhibits a broad range of bioactivities and pharmacological properties. It demonstrates significant anticonvulsive activity in bicuculline (BIC) and picrotoxin (PCR) induced seizure tests in mice, with effective doses (ED50) of 220.0 umol.kg^-1 and 210.0 umol.kg^-1, respectively. Moreover, at a dosage of 100 mg/kg, it provides sustained protection against picrotoxin-induced convulsions. In terms of metabolism, Vigabatrin has a very short half-life of 0.005 hours at a concentration of 1 mM and a dissociation constant (pKa) of 9.5. It inhibits GABA transaminase (GABA-T) activity in vivo with an IC50 value of 41,210.0 nM and increases brain GABA levels, suggesting potential implications for regulating GABA neurotransmission in the brain. The compound also shows various activities in vitro; it inhibits gamma-aminobutyric acid aminotransferase from the pig brain with a Ki of 3200000.0 nM and a K inact rate of 0.37 min^-1, as well as rat GABA-AT with a Ki of 10,000,000.0 nM. Vigabatrin exhibits inhibitory activity against several human transporters, including BSEP, MRP2, MRP3, and MRP4, with IC50 values greater than 133000.0 nM. While it indicates moderate hepatic toxicity and potential retinotoxicity in specific test conditions, it shows no significant hepatic side effects and good aqueous solubility characteristics. Additionally, Vigabatrin demonstrates significant penetration and inhibition activities related to sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells. It has been evaluated for potential antiviral activity against SARS-CoV-2, showing some level of inhibition of virus-induced cytotoxicity and 3CL-Pro protease activity. It also shows a range of potencies in bioactivity assays against various targets, including enzymes and receptors, albeit mostly with high AC50 values, indicating relatively weak interactions. Overall, Vigabatrin has shown potential in modulating GABAergic activity and various other bioactivities, but further investigation is needed to fully understand its pharmacological profile and therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid.
别名	氨己烯酸, Vigabatrine, Sabril

化学信息

分子量	129.16
分子式	C₆H₁₁NO₂
CAS No.	60643-86-9
Smiles	NC(CCC(O)=O)C=C
密度	1.108?g/mL?at 25?°C(lit.)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: < 1 mg/mL (insoluble)

H2O: 100 mg/mL (774.23 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	7.7423 mL	38.7117 mL	77.4234 mL	387.1168 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL	77.4234 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL	38.7117 mL
20 mM	0.3871 mL	1.9356 mL	3.8712 mL	19.3558 mL
50 mM	0.1548 mL	0.7742 mL	1.5485 mL	7.7423 mL
100 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8712 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。