Name: AS2521780
Brand: TargetMol
SKU: T14328
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 21,600

3-6月

50 mg

¥ 28,800

3-6月

100 mg

¥ 37,500

3-6月

生物活性

产品描述	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
靶点活性	PKCα:160 nM, PKCδ:160 nM, PKCθ:0.48 nM, PKCε:18 nM
体外活性	AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells and it also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1]. AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM). Which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases.
体内活性	AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1].

化学信息

分子量	547.76
分子式	C₃₀H₄₁N₇OS
CAS No.	1214726-89-2
Smiles	C(NC=1C(C#N)=CN=C(NCC2=C(SC)N=CC=C2)N1)C34C[C@@]5([C@@H](NC[C@@H]6CC[C@@H](O)CC6)[C@](C3)(CC(C4)C5)[H])[H]
密度	1.29 g/cm3 (Predicted)