Temgicoluril

Name: Temgicoluril
Brand: TargetMol
SKU: T9424
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.8%

货号 T9424Cas号 10095-06-4

别名 Tetramethylglycoluril, mebikar

Temgicoluril (mebikar) 具有抗焦虑活性，作用于GABA 受体。

Temgicoluril

一键复制产品信息

很棒

纯度: 99.8%

货号 T9424 别名 Tetramethylglycoluril, mebikarCas号 10095-06-4

Temgicoluril (mebikar) 具有抗焦虑活性，作用于GABA 受体。

规格	价格	库存
10 mg	¥ 133	现货
25 mg	¥ 206	现货
50 mg	¥ 296	现货

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纯度: 99.8%

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COA HNMR LCMS 产品操作手册

产品介绍

Temgicoluril AI Summary

Temgicoluril exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a 10 µM concentration with a 4.43% inhibition after 48 hours, as determined by high content imaging. In VERO-6 cells, the inhibition was -0.21% under the same conditions. Moreover, the compound demonstrates moderate antiviral activity against the SARS-CoV-2 USA-WA1/2020 strain in HRCE cells with a hit score of 0.1618. It also acts as an inhibitor of the SARS-CoV-2 3CL-Pro protease, showing 12.24% inhibition at 20 µM concentration. However, its potency in terms of inhibition is limited, with an IC50 value greater than 20000 nM in VERO-6 cells. In enzymatic assays, Temgicoluril has a moderate inhibitory effect on human HDAC6 activity with an inhibition of 6.15% using a commercial peptide substrate and -1.23% using a custom substrate. The compound displays binding affinity towards various receptors and transporters but exhibits minimal bioactivity, with AC50 values greater than 30,000 nM for all tested targets, indicating low or no activity in these assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Temgicoluril (mebikar) acts on GABA Receptor.
别名	Tetramethylglycoluril, mebikar

化学信息

分子量	198.22
分子式	C₈H₁₄N₄O₂
CAS No.	10095-06-4
Smiles	CN1C2C(N(C)C1=O)N(C)C(=O)N2C
密度	1.237 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (630.61 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (20.18 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0449 mL	25.2245 mL	50.4490 mL	252.2450 mL
5 mM	1.0090 mL	5.0449 mL	10.0898 mL	50.4490 mL
10 mM	0.5045 mL	2.5224 mL	5.0449 mL	25.2245 mL
20 mM	0.2522 mL	1.2612 mL	2.5224 mL	12.6122 mL
50 mM	0.1009 mL	0.5045 mL	1.0090 mL	5.0449 mL
100 mM	0.0504 mL	0.2522 mL	0.5045 mL	2.5224 mL