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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Vilazodone

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纯度: 99.61%

货号 T1279Cas号 163521-12-8

别名 维拉佐酮, SB659746A, EMD 68843

Vilazodone (SB659746A) 是一种可口服的选择性 5 -羟色胺再摄取抑制剂 (SSRI) 和部分5-HT1A 受体激动剂。它有抗抑郁作用，可用于抑郁症和情绪性疾病的研究。

Vilazodone
其他形式的 “Vilazodone”:
Vilazodone-d8
Vilazodone Hydrochloride

Vilazodone

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Rating icon 很棒

纯度: 99.61%

货号 T1279 别名 维拉佐酮, SB659746A, EMD 68843Cas号 163521-12-8

Vilazodone (SB659746A) 是一种可口服的选择性 5 -羟色胺再摄取抑制剂 (SSRI) 和部分5-HT1A 受体激动剂。它有抗抑郁作用，可用于抑郁症和情绪性疾病的研究。

规格价格库存数量
1 mg
¥ 342
现货
5 mg
¥ 953
现货
10 mg
¥ 1,439
现货
50 mg
¥ 2,418
现货
1 mL x 10 mM (in DMSO)
¥ 997
现货
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纯度: 99.61%
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产品介绍

生物活性
产品描述
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from the synaptic cleft while stimulating the release of 5-HT into the synaptic cleft. This increases the concentration of 5-HT in the synaptic cleft and potentiates serotonergic neurotransmission in the central nervous system.
别名维拉佐酮, SB659746A, EMD 68843
化学信息
分子量441.52
分子式C26H27N5O2
CAS No.163521-12-8
SmilesNC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
密度1.34 g/cm3 (Predicted)
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 68.57 mg/mL (155.3 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.53 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.2649 mL11.3245 mL22.6490 mL113.2452 mL
5 mM0.4530 mL2.2649 mL4.5298 mL22.6490 mL
10 mM0.2265 mL1.1325 mL2.2649 mL11.3245 mL
20 mM0.1132 mL0.5662 mL1.1325 mL5.6623 mL
50 mM0.0453 mL0.2265 mL0.4530 mL2.2649 mL
100 mM0.0226 mL0.1132 mL0.2265 mL1.1325 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Vilazodone exhibits potent bioactivities related to serotonin regulation and has demonstrated interactions with various neurotransmitter systems. It has a high affinity for the human 5-HT1A receptor (Ki = 0.2 nM) and exhibits agonist activity at this receptor with an EC50 value of 0.12 nM. The compound effectively inhibits the serotonin transporter (SERT) with an IC50 value ranging from 0.4 to 0.5 nM, indicating its potential to modulate serotonin levels. Additionally, it shows inhibitory activity against the dopamine receptors (D2, D3, D4), adrenergic receptors (alpha-1, alpha-2), histamine H1 receptor, and rat cortex acetylcholinesterase (AChE) with an IC50 of 21300.0 nM. In antiviral assays, Vilazodone displays activity against SARS-CoV-2 with modest inhibition rates, including a hit score of 0.1122 in HRCE cells and a 0.71% inhibition rate of SARS-CoV-2 induced cytotoxicity in VERO-6 cells. It also inhibits the SARS-CoV-2 3CL-Pro protease by approximately 9.82% at 20 µM. Metabolic stability of Vilazodone is moderate to low in liver microsomes, with half-lives around 0.4-0.474 hours in rat, mouse, and human models. These findings, combined with good permeability in PAMPA-BBB assays and moderate inhibition of several cytochrome P450 enzymes, suggest potential challenges in drug-drug interactions and systemic exposure. The compound also demonstrates antidepressant properties in mice, reducing immobility time by 60% at a dose of 40 mg/kg for 7 days. It exhibits cytotoxicity in human HepG2 cells with an IC50 value of 6100.0 nM. Overall, Vilazodone is a promising serotonin modulator with potential therapeutic implications in serotonin-related disorders, although further research is needed to address its metabolic stability and broad receptor interactions..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

VilazodoneViibrydSLC6A4Sert (Sodium-dependent)SERTSerotoninTransporterSerotonin TransporterSerotonin ReceptorMDDmajor depressive disorderInhibitorinhibitEMD-68843EMD68843Affective Disorder5-hydroxytryptamine Receptor5-HTT5HTReceptor5-HT Receptor5HT Receptor5-HT
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