Decynium 22

Name: Decynium 22
Brand: TargetMol
SKU: T22714
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T22714Cas号 977-96-8

别名 1,1'-二乙基-2,2'-碘化氰

Decynium 22 是有机阳离子转运蛋白和单胺转运蛋白的抑制剂，具有抗抑郁作用。

Decynium 22

一键复制产品信息

很棒

纯度: 99.92%

货号 T22714 别名 1,1'-二乙基-2,2'-碘化氰Cas号 977-96-8

Decynium 22 是有机阳离子转运蛋白和单胺转运蛋白的抑制剂，具有抗抑郁作用。

规格	价格	库存	数量
50 mg	¥ 243	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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资源下载:

COA HNMR LCMS HPLC 产品操作手册

产品介绍

Decynium 22 AI Summary

Decynium 22 exhibits potent activity in displacing [3H]prazosin from alpha1 adrenoceptors in C57BL/6 mouse hippocampal homogenates at concentrations ranging from 0.0001 µM to 0.01 µM, achieving activity levels between 81.2% and 100.0%. However, at a higher concentration of 30 µM, the compound shows a negative activity of -5.0%. It has an IC50 value of 60.0 nM in this assay. The compound also displays anti-depressant-like effects in mice, reducing immobility time in a tail suspension test following intraperitoneal administration at doses of 1 mg/kg and 3.2 mg/kg. Additionally, Decynium 22 inhibits the Organic Cation Transporter 3 (OCT3, SLC22A3) with an IC50 value of 400.0 nM, as measured by a phenotypic impedance-based assay detecting changes in cell morphology due to MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells. Moreover, it exhibits cytotoxic activity against human HepG2 cells, with an IC50 value of 1000.0 nM as determined by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Decynium 22 is a plasma membrane monoamine transporter (PMAT) inhibitor
别名	1,1'-二乙基-2,2'-碘化氰

化学信息

分子量	454.35
分子式	C₂₃H₂₃IN₂
CAS No.	977-96-8
Smiles	CCN1/C(=C/C2=[N+](C3=CC=CC=C3C=C2)CC)/C=CC4=CC=CC=C41.[I-]
密度	1.3883 g/cm3 (Estimated)
颜色	Black
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (121.05 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.4 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2009 mL	11.0047 mL	22.0095 mL	110.0473 mL
5 mM	0.4402 mL	2.2009 mL	4.4019 mL	22.0095 mL
10 mM	0.2201 mL	1.1005 mL	2.2009 mL	11.0047 mL
20 mM	0.1100 mL	0.5502 mL	1.1005 mL	5.5024 mL
50 mM	0.0440 mL	0.2201 mL	0.4402 mL	2.2009 mL
100 mM	0.0220 mL	0.1100 mL	0.2201 mL	1.1005 mL