Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SLC26A3-IN-1 是一种阴离子交换蛋白 SLC26A3 的抑制剂 ,IC50值为340 nM。SLC26A3 属于溶质载体 (SLC) 蛋白,是 SLC26 家族成员之一。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调,参与氯化物和草酸盐的肠道吸收且与氯离子丢失性腹泻有关。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,900 | 现货 | ||
10 mg | ¥ 4,290 | 现货 | ||
25 mg | ¥ 6,850 | 现货 | ||
50 mg | ¥ 9,270 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 24,800 | 现货 |
产品描述 | SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM.SLC26A3 is a solute carrier (SLC) protein and a member of the SLC26 family, which has a wide range of anionic specificities for chloride, bicarbonate, sulfate, and oxalate.SLC26A3 is downregulated in adenomas (DRA) and is involved in the intestinal absorption of chloride and oxalate and is associated with chloride-losing diarrhea. SLC26A3 is downregulated in adenomas (DRA), is involved in the intestinal absorption of chloride and oxalate, and is associated with chloride-losing diarrhea. |
靶点活性 | SLC26A3:340 Nm |
体外活性 | SLC26A3-IN-1 (Compound 4a) (10 μM; 10 min) inhibitory rate on SLC26A3 is 87%.[1] |
分子量 | 358.39 |
分子式 | C23H18O4 |
CAS No. | 307552-53-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (139.51 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7903 mL | 13.9513 mL | 27.9026 mL | 69.7564 mL |
5 mM | 0.5581 mL | 2.7903 mL | 5.5805 mL | 13.9513 mL | |
10 mM | 0.279 mL | 1.3951 mL | 2.7903 mL | 6.9756 mL | |
20 mM | 0.1395 mL | 0.6976 mL | 1.3951 mL | 3.4878 mL | |
50 mM | 0.0558 mL | 0.279 mL | 0.5581 mL | 1.3951 mL | |
100 mM | 0.0279 mL | 0.1395 mL | 0.279 mL | 0.6976 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SLC26A3-IN-1 307552-53-0 Metabolism transporter Inhibitor inhibitor inhibit