Name: SCH 42495
Brand: TargetMol
SKU: T12641L
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述	SCH 42495 is an orally active neutral metalloendopeptidase inhibitor. SCH 42495 is the orally active ethyl ester prodrug of SCH 42354.
体外活性	SCH 42354 inhibits the hydrolysis of leu-enkephalin and ANF (IC50: 8.3 and 10.0 nM, respectively) [1].
体内活性	SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively. SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a significant reduction in pulmonary vascular remodeling and ventricular hypertrophy in hypoxic rats after 10 days. Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) resulting in a decrease in cardiovascular remodeling secondary to chronic hypoxia in rats [1][2].

化学信息

分子量	411.58
分子式	C₂₀H₂₉NO₄S₂
CAS No.	136511-43-8
Smiles	[C@H](CC1=C(C)C=CC=C1)(C(N[C@H](C(OCC)=O)CCSC)=O)CSC(C)=O
密度	1.158 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

SCH 42495