Name: Elimusertib hydrochloride(1876467-74-1 free base)
Brand: TargetMol
SKU: T10468
Price: 287 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 287

现货

5 mg

¥ 792

现货

10 mg

¥ 1,190

现货

25 mg

¥ 2,390

现货

50 mg

¥ 3,400

现货

100 mg

¥ 4,750

现货

200 mg

¥ 6,390

现货

1 mL x 10 mM (in DMSO)

¥ 852

现货

产品介绍

生物活性

产品描述	Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
靶点活性	ATR:7 nM
体外活性	Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1].
体内活性	In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2].
别名	BAY-1895344 hydrochloride

化学信息

分子量	411.89
分子式	C₂₀H₂₂ClN₇O
Smiles	CN1N=CC=C1C2=CC(N3[C@@H](COCC3)C)=NC4=C(N=CC=C24)C5=CC=NN5.[H]Cl
密度	no data available

储存&溶解度

存储

keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (121.39 mM), Sonication and heating are recommended.

H2O: 48 mg/mL (116.54 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4278 mL	12.1392 mL	24.2783 mL	121.3916 mL
5 mM	0.4856 mL	2.4278 mL	4.8557 mL	24.2783 mL
10 mM	0.2428 mL	1.2139 mL	2.4278 mL	12.1392 mL
20 mM	0.1214 mL	0.6070 mL	1.2139 mL	6.0696 mL
50 mM	0.0486 mL	0.2428 mL	0.4856 mL	2.4278 mL
100 mM	0.0243 mL	0.1214 mL	0.2428 mL	1.2139 mL

体内实验配液计算器