规格

价格

库存

数量

1 mg

¥ 328

现货

2 mg

¥ 483

现货

5 mg

¥ 828

现货

10 mg

¥ 1,580

现货

25 mg

¥ 3,380

现货

50 mg

¥ 4,890

现货

100 mg

¥ 6,870

现货

1 mL x 10 mM (in DMSO)

¥ 913

现货

生物活性

产品描述	NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
靶点活性	SK2:0.60 μM (kd), SK1:0.42 μM (kd), SK3:0.73 μM (kd)
体外活性	It is found that tested in excised patches, the inhibition by NS8593 (compound 14) decreased as the intracellular [Ca2+] is increased and that NS8593 is equipotent when applied from either the intracellular or the extracellular side of the cell membrane.?A HEK293 cell transiently transfected with hSK3 channels is inhibited by 80% upon application of 100 nM apamin and by 75% after application of 300 nM NS8593.
体内活性	NS8593 is able to affect firing pattern and firing rate?of dopaminergic neurons in vivo in C57Bl/6 mice[1].
别名	NS8593 HCl

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (266.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.01 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO