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Indole-3-butyric acid

Name: Indole-3-butyric acid
Brand: TargetMol
SKU: T6361
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T6361Cas号 133-32-4

别名 IBA, Hormodin, 3-吲哚丁酸, 3-Indolebutyric acid

Indole-3-butyric acid (IBA) 是一种植物生长素。它能够促进草本植物和木本观赏植物生根，并用于提高果实率。

Indole-3-butyric acid

一键复制产品信息

很棒

纯度: 99.92%

货号 T6361 别名 IBA, Hormodin, 3-吲哚丁酸, 3-Indolebutyric acidCas号 133-32-4

Indole-3-butyric acid (IBA) 是一种植物生长素。它能够促进草本植物和木本观赏植物生根，并用于提高果实率。

规格	价格	库存	数量
5 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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产品介绍

Indole-3-butyric acid AI Summary

Indole-3-butyric acid exhibits a broad spectrum of bioactivities. It acts as an antagonist at the human T1R2/T1R3 receptor with an IC50 value greater than 1,000,000 nM, inhibiting sucralose-induced intracellular calcium mobilization in HEK293E cells. In receptor-based assays, it shows agonist activity towards retinoid X receptor alpha, estrogen receptor alpha, androgen receptor, peroxisome proliferator-activated receptor delta and gamma, and the ARE signaling pathways, with potencies ranging from 13.3 nM to 61,130.6 nM. It also displays antagonist activity towards the androgen receptor. For enzymatic inhibition, Indole-3-butyric acid inhibits electric eel AChE (-10.87%) and horse BChE (-5.54%) at 2 mg/mL. In terms of antibacterial properties, it inhibits metallo-beta-lactamase VIM-2 from Pseudomonas aeruginosa, with an IC50 of 757,000 nM and Kd of 274,000 nM, as well as Klebsiella pneumoniae NDM-1 with an IC50 of 1,946,000 nM and Kd of 806,000 nM. Moreover, it shows activity against Klebsiella pneumoniae OXA-48 (IC50 of 480,000 nM, Kd of 430,000 nM) and LOX with an IC50 of 17,820 nM. In antiviral assays, Indole-3-butyric acid inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 16.23% at 10 µM after 48 hours, but demonstrates significantly lower inhibition in VERO-6 cells (-0.05%). For SARS-CoV-2 3CL-Pro protease, it shows 1.767% inhibition at 20 µM. Additionally, it has fungicidal activity against various fungi like Macrophomina phaseoli, Rhizoctonia solani, Pythium debaryanum, and Fusarium culmorum with IC50 values ranging from 249.0 to 699.0 µg/mL, and promotes root formation in Vigna mungo cuttings at 1 x 10^-4 M, matching the activity of IBA. Finally, it exhibits inhibitory activity against the human HDAC6 enzyme with -15.75% inhibition in one enzymatic assay and -2.0% in another..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
别名	IBA, Hormodin, 3-吲哚丁酸, 3-Indolebutyric acid

化学信息

分子量	203.24
分子式	C₁₂H₁₃NO₂
CAS No.	133-32-4
Smiles	OC(=O)CCCC1=CNC2=CC=CC=C12
密度	1.1255 g/cm3 (Estimated)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 39 mg/mL (191.89 mM), Sonication is recommended.

DMSO: 50 mg/mL (246.01 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (12.3 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9203 mL	24.6015 mL	49.2029 mL	246.0146 mL
5 mM	0.9841 mL	4.9203 mL	9.8406 mL	49.2029 mL
10 mM	0.4920 mL	2.4601 mL	4.9203 mL	24.6015 mL
20 mM	0.2460 mL	1.2301 mL	2.4601 mL	12.3007 mL
50 mM	0.0984 mL	0.4920 mL	0.9841 mL	4.9203 mL
100 mM	0.0492 mL	0.2460 mL	0.4920 mL	2.4601 mL