Name: γ-Secretase-IN-1
Brand: TargetMol
SKU: T3521
Price: 1320 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,320

现货

5 mg

¥ 3,850

现货

10 mg

¥ 5,490

现货

25 mg

¥ 8,230

现货

50 mg

¥ 10,900

现货

100 mg

¥ 14,900

现货

200 mg

¥ 19,800

现货

1 mL x 10 mM (in DMSO)

¥ 4,160

现货

产品介绍

生物活性

产品描述	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
靶点活性	β-Amyloid (1–40):0.24 nM, Notch:0.24 nM, β-Amyloid (1–42):0.37 nM
体外活性	At a concentration of 50 μM, compound E reduces the proliferation of T47D and MCF-7 cell lines by less than 50% [2].
别名	Compound E

化学信息

分子量	490.5
分子式	C₂₇H₂₄F₂N₄O₃
CAS No.	209986-17-4
Smiles	C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O
密度	1.31 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (163.1 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0387 mL	10.1937 mL	20.3874 mL	101.9368 mL
5 mM	0.4077 mL	2.0387 mL	4.0775 mL	20.3874 mL
10 mM	0.2039 mL	1.0194 mL	2.0387 mL	10.1937 mL
20 mM	0.1019 mL	0.5097 mL	1.0194 mL	5.0968 mL
50 mM	0.0408 mL	0.2039 mL	0.4077 mL	2.0387 mL
100 mM	0.0204 mL	0.1019 mL	0.2039 mL	1.0194 mL

体内实验配液计算器