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Imazalil
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很棒纯度: 99.23%
货号 T1113Cas号 35554-44-0
别名 抑霉唑, Enilconazole, chloramizole
Imazalil (Enilconazole) 是一种广泛用于农业的杀真菌剂，尤其是柑橘类水果的生长, 也是兽用局部抗真菌剂。
Imazalil
一键复制产品信息 很棒纯度: 99.23%
货号 T1113 别名 抑霉唑, Enilconazole, chloramizoleCas号 35554-44-0
Imazalil (Enilconazole) 是一种广泛用于农业的杀真菌剂，尤其是柑橘类水果的生长, 也是兽用局部抗真菌剂。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 125 | 现货 | |
| 50 mg | ¥ 173 | 现货 | |
| 100 mg | ¥ 248 | 现货 | |
| 500 mg | ¥ 588 | 现货 | |
| 1 g | ¥ 867 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 273 | 现货 |
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产品介绍
Imazalil AI Summary
Imazalil exhibits a broad spectrum of bioactivities and therapeutic potential. It shows significant antifungal activity against various fungi, including Aspergillus fumigatus, Drechslera sorokiniana, and Fusarium culmorum, with MIC values ranging from 0.1 to 5.0 μg/mL. Additionally, it is effective against Colletotrichum capsici, with an ED50 of less than 5.0 μgAi/mL. The compound demonstrates antiviral properties, including moderate inhibition of SARS-CoV-2 in Vero E6 cells and HRCE cells, and has an IC50 value greater than 20,000 nM for SARS-CoV-2 induced cytotoxicity in VERO-6 cells.
Imazalil exhibits diverse bioactivities, including inhibition of mitochondrial division, rescue of yeast growth from Plasmodium Falciparum HSP40-mediated toxicity, and antagonism of thyroid hormone receptor beta signaling. It inhibits the delayed death of malarial parasite plastid, antagonizes farnesoid X receptor signaling, and shows activity as an agonist for peroxisome proliferator-activated receptor gamma signaling and vitamin D receptor signaling. The compound also acts as an inverse agonist for GLP-1 receptor and activates both rat and human pregnane X receptor signaling pathways. It inhibits survival of Plasmodium falciparum in red blood cells, human tyrosyl-DNA phosphodiesterase 1, TDP-43, and alpha-syn.
Moreover, Imazalil inhibits IDO1 enzyme activity with an IC50 value of 23,000 nM and demonstrates cytotoxicity against mouse P815B cells with an LD50 value greater than 25.0 μM. In the enzymatic assay, it shows -0.06% inhibition of human HDAC6 enzyme using a commercial peptide substrate and -8.66% inhibition using a custom peptide substrate.
While the compound exhibited beta-blocking activity in stepwise linear discriminate analysis, it was inactive in this specific assay with an activity value of -3.17. Overall, the diverse bioactivities of Imazalil suggest its potential therapeutic applications in treating fungal infections, malaria, viral infections, and metabolic disorders..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Enilconazole is an Agricultural fungicide Enilconazole is a fungicide widely used in agriculture, particularly in the growing of citrus fruits. It is also called Imazalil (Enilconazole), Chloramizole, Freshgard, Fungaflor, and Nuzone |
| 别名 | 抑霉唑, Enilconazole, chloramizole |
| 分子量 | 297.18 |
| 分子式 | C14H14Cl2N2O |
| CAS No. | 35554-44-0 |
| Smiles | C(CN1C=CN=C1)(OCC=C)C2=C(Cl)C=C(Cl)C=C2 |
| 密度 | 1.348 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 25 mg/mL (84.12 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.73 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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