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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Vinburnine

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纯度: 99.83%

货号 T2149Cas号 4880-88-0

别名 长春布宁, Vincamone, L-Eburnamonine, Eburnalritardo, (-)-Vincamone, (-)-Eburnamonine

Vinburnine (Eburnalritardo) 是一种长春花生物碱，是长春胺的代谢物和是血管扩张剂。

Vinburnine
其他形式的 “Vinburnine”:
EburnamonineT131582
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Vinburnine

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Rating icon 很棒

纯度: 99.83%

货号 T2149 别名 长春布宁, Vincamone, L-Eburnamonine, Eburnalritardo, (-)-Vincamone, (-)-EburnamonineCas号 4880-88-0

Vinburnine (Eburnalritardo) 是一种长春花生物碱，是长春胺的代谢物和是血管扩张剂。

规格价格库存数量
25 mg
¥ 332
现货
50 mg
¥ 467
现货
100 mg
¥ 671
现货
1 mL x 10 mM (in DMSO)
¥ 739
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纯度: 99.71%
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产品介绍

Vinburnine AI Summary
Vinburnine exhibits a wide range of bioactivities encompassing antimalarial, anticancer, antiviral, and DNA replication-modulating properties. It demonstrates significant inhibition of the malarial parasite plastid, with potency values ranging from 2332.3 nM to 13115.4 nM, and it inhibits growth in various human tumor cell lines with GI50 values between 1309.18 nM and 100000.0 nM. The compound also induces DNA re-replication in normal breast cells and colon adenocarcinoma cells, and shows potency in inhibiting interactions related to Hepatitis C Virus, Vif-A3G interactions, GLP-1 Receptor, and ATXN expression. In addition, Vinburnine inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence and absence of CPT and exhibits synthetic lethality in tumor cells as well as inhibition of Vaccinia Orthopoxvirus. The compound blocks the entry of Ebola Virus in various assays. It also shows significant activity as an acetylcholinesterase (AChE) inhibitor but exhibits much lower activity against horse butyrylcholinesterase (BChE). Cytotoxicity assays reveal that Vinburnine has potent cytotoxic effects on various human cell lines, including KMS-12-BM, U266, RPMI8226, LNCAP, and MDA-MB-231 cells, with an IC50 value of 41800.0 nM against MDA-MB-231 cells after 96 hours. It also demonstrates high inhibition of sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells, suggesting potent inhibitory effects on these transporters. Furthermore, Vinburnine shows antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentrations, with various degrees of efficacy. The compound also exhibits 9.522% inhibition of SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM and moderate inhibition of human HDAC6 in enzymatic assays. Overall, Vinburnine is a multifunctional compound with potential applications in treating malaria, cancer, and viral infections, including SARS-CoV-2..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.
别名长春布宁, Vincamone, L-Eburnamonine, Eburnalritardo, (-)-Vincamone, (-)-Eburnamonine
化学信息
分子量294.39
分子式C19H22N2O
CAS No.4880-88-0
Smiles[H][C@]12N3CCC[C@@]1(CC)CC(=O)n1c2c(CC3)c2ccccc12
密度1.34 g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 2.95 mg/mL (10.02 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.3969 mL16.9843 mL33.9685 mL169.8427 mL
5 mM0.6794 mL3.3969 mL6.7937 mL33.9685 mL
10 mM0.3397 mL1.6984 mL3.3969 mL16.9843 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

VinburnineInhibitorinhibitEburnamonineDrugMetaboliteDrug Metabolite
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