Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC 50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 ranging from 0.018 to 0.025 nM). Additionally, Azvudine hydrochloride effectively inhibits NRTI-resistant viral strains.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 834 | 5日内发货 | ||
5 mg | ¥ 1,390 | 5日内发货 | ||
25 mg | ¥ 5,630 | 6-8周 | ||
50 mg | ¥ 7,320 | 6-8周 | ||
100 mg | ¥ 11,600 | 6-8周 |
Azvudine hydrochloride 的其他形式现货产品:
产品描述 | Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC 50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 ranging from 0.018 to 0.025 nM). Additionally, Azvudine hydrochloride effectively inhibits NRTI-resistant viral strains. |
靶点活性 | HIV-2:0.018-0.02 nM (EC50), HIV-1:0.03-6.92 nM (EC50) |
体外活性 | Azvudine (RO-0622) hydrochloride displays strong inhibition on wild-type HIV-1 IIIB and HIV-1 RF with an EC 50 ranging from 30 to 110 pM. The EC 50 values of Azvudine hydrochloride against HIV-1 KM018 , HIV-1 TC-1 and HIV-1 WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-1 74V , PIs-resistant strains HIV-1 L10R/M46I/L63P/V82T/I84V and HIV-1 RF V82F/184V , and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T . The EC 50 values of Azvudine hydrochloride against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. |
别名 | RO-0622 hydrochloride, Azvudine hydrochloride, FNChydrochloride |
分子量 | 322.68 |
分子式 | C9H12ClFN6O4 |
CAS No. | 1333126-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Azvudine hydrochloride 1333126-31-0 RO-0622 Hydrochloride RO-0622 hydrochloride RO 0622 Hydrochloride RO0622 Hydrochloride FNChydrochloride Azvudine Hydrochloride Inhibitor inhibitor inhibit