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BNC105

Name: BNC105
Brand: TargetMol
SKU: T14694
Price: 569 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 96.57%

货号 T14694Cas号 945771-74-4

BNC105 是一种微管蛋白聚合抑制剂，具有抗增殖和破坏肿瘤血管的特性。

为众多的药物研发团队赋能，

让新药发现更简单！

BNC105

一键复制产品信息

很棒

纯度: 96.57%

货号 T14694Cas号 945771-74-4

BNC105 是一种微管蛋白聚合抑制剂，具有抗增殖和破坏肿瘤血管的特性。

规格	价格	库存
1 mg	¥ 569	现货
5 mg	¥ 1,630	现货
10 mg	¥ 2,390	现货
25 mg	¥ 3,760	现货
50 mg	¥ 4,970	现货
100 mg	¥ 6,780	现货
200 mg	¥ 9,130	现货
1 mL x 10 mM (in DMSO)	¥ 1,380	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 96.57%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

BNC105 AI Summary

BNC105 exhibits potent antiproliferative activity against a spectrum of human cancer cell lines, including LoVo, SKOV3, A375, A431, MDA-MB-231, Calu6, DU145, U87MG, HAAE1, HUVEC, MCF7, AU565, BT549, and MDR-1 overexpressing 786-0 cells, with low IC50 values ranging from 0.01 nM to 25.0 nM. It also displays cytotoxicity against A2780, A2780/ADR, and A2780cis cells. The compound inhibits tubulin polymerization with an IC50 of 3000.0 nM. In vivo studies have demonstrated good drug uptake in a breast cancer mouse model, and it possesses favorable pharmacokinetic properties in Sprague-Dawley rats, including a moderate half-life of 3.5 hours, a volume of distribution (Vd) at steady state of 7.1 L.kg^-1, and high plasma protein binding of 81.4%. The antiproliferative efficacy against MDR-1 overexpressing cells is enhanced by the MDR1 inhibitor verapamil. Additionally, BNC105 exhibits antiviral activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with measured inhibition percentages of 19.89% and 3.11%, respectively, at a concentration of 10 µM after 48 hours. It also inhibits SARS-CoV-2 3CL-Pro protease with 14.01% inhibition at 20 µM concentration. Furthermore, the compound shows inhibitory activity against human HDAC6, achieving an inhibition rate of 31.91% using a commercial peptide substrate and 11.56% using a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.

化学信息

分子量	372.37
分子式	C₂₀H₂₀O₇
CAS No.	945771-74-4
Smiles	COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(C)oc2c1O
密度	1.261 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 0.1 mg/mL (insoluble)

DMSO: 25 mg/mL (67.14 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2 mg/mL (5.37 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6855 mL	13.4275 mL	26.8550 mL	134.2750 mL
5 mM	0.5371 mL	2.6855 mL	5.3710 mL	26.8550 mL
10 mM	0.2686 mL	1.3428 mL	2.6855 mL	13.4275 mL
20 mM	0.1343 mL	0.6714 mL	1.3428 mL	6.7138 mL
50 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6855 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。