规格

价格

库存

数量

1 mg

¥ 108

现货

5 mg

¥ 213

现货

10 mg

¥ 345

现货

25 mg

¥ 646

现货

50 mg

¥ 987

现货

100 mg

¥ 1,650

现货

1 mL x 10 mM (in DMSO)

¥ 248

现货

生物活性

产品描述	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
体外活性	Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM[1]. Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively[1].
体内活性	Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase[1]. Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats[2]. Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder[3].
别名	西维来司钠四水合物, Sivelestat Sodium Hydrate, Sivelestat Sodium, ONO-5046 sodium tetrahydrate, ONO5046 sodium tetrahydrate, ONO-5046, ONO5046, ONO 5046, Elaspol sodium tetrahydrate, Elaspol

化学信息

分子量	528.51
分子式	C₂₀H₂₉N₂NaO₁₁S
CAS No.	201677-61-4
Smiles	O.O.O.O.[NaH].CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 225 mg/mL (425.73 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8921 mL	9.4606 mL	18.9211 mL	94.6056 mL
5 mM	0.3784 mL	1.8921 mL	3.7842 mL	18.9211 mL
10 mM	0.1892 mL	0.9461 mL	1.8921 mL	9.4606 mL
20 mM	0.0946 mL	0.4730 mL	0.9461 mL	4.7303 mL
50 mM	0.0378 mL	0.1892 mL	0.3784 mL	1.8921 mL
100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.9461 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Sivelestat sodium tetrahydrate

Sivelestat sodium tetrahydrate

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Sivelestat sodium tetrahydrate

Sivelestat sodium tetrahydrate