规格

价格

库存

数量

1 mg

¥ 543

现货

2 mg

¥ 789

现货

5 mg

¥ 1,580

现货

10 mg

¥ 2,690

现货

25 mg

¥ 4,490

现货

50 mg

¥ 6,420

现货

100 mg

¥ 8,790

现货

1 mL x 10 mM (in DMSO)

¥ 1,380

现货

生物活性

产品描述	VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
靶点活性	HSP90:25 nM
体外活性	在人卵巢肿瘤模型中,腹腔注射VER-49009（4 mg/kg）能够诱导HSP90与ERBB2的解离.在无胸腺的小鼠中,静脉注射VER-49009（20 mg/kg ）能够发挥有效作用.
体内活性	VER-49009能够诱导HSP72和HSP27与与其结合蛋白解离,导致细胞周期停滞。在重组的酵母Hsp90蛋白中（IC50=167 nM）,VER-49009能够抑制內源性ATP酶活性。在肝纤维化的治疗中,VER-49009能够诱导肝细胞CFSC在G2期停滞积累,抑制细胞生长。
激酶实验	Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.
细胞实验	Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)
别名	VER-49009, VER 49009, CCT0129397

化学信息

分子量	387.82
分子式	C₁₉H₁₈ClN₃O₄
CAS No.	940289-57-6
Smiles	c1(c(cc(c(c1)c1c(c([nH]n1)C(=O)NCC)c1ccc(cc1)OC)O)O)Cl
密度	no data available
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (183.07 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO