Coumarin-3-carboxylic acid

Name: Coumarin-3-carboxylic acid
Brand: TargetMol
SKU: TJS0339
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.88%

货号 TJS0339Cas号 531-81-7

别名 香豆素-3-羧酸, 3-Carboxycoumarin

Coumarin-3-carboxylic acid (3-Carboxycoumarin) 是一种合成香豆素的重要起始化合物。其中香豆素是具有多种生物活性的天然产物。它的镧系复合物对 K-562 细胞具有抗增殖活性。

Coumarin-3-carboxylic acid

一键复制产品信息

很棒

纯度: 99.88%

货号 TJS0339 别名 香豆素-3-羧酸, 3-CarboxycoumarinCas号 531-81-7

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Coumarin-3-carboxylic acid AI Summary

Coumarin-3-carboxylic acid demonstrates a wide array of bioactivities, including inhibitory effects on human and mouse carbonic anhydrase isoforms with potencies ranging from nanomolar to micromolar levels. It also functions as an agonist of the Thyroid Stimulating Hormone Receptor and GPR35, and as an inhibitor of ROR gamma transcriptional activity. Additionally, it induces synthetic lethality in tumor cells producing 2HG and shows significant inhibitory activity against various targets, including the Influenza NS1 Protein, AmpC Beta-Lactamase, GCN5L2, Histone Lysine Methyltransferase G9a, firefly luciferase, and MBNL1-poly(CUG) RNA binding. Its antibacterial potential is highlighted by binding affinities to methicillin-resistant Staphylococcus aureus (MRSA) strains and Klebsiella pneumoniae. However, it shows minimal inhibitory activity against human Protein-tyrosine phosphatase 1B and Mao-A while demonstrating significant inhibition of MAO-B. Furthermore, Coumarin-3-carboxylic acid displays antifungal activity against Aspergillus species, has antioxidant properties as shown by DNA oxidation reduction and ABTS+ scavenging activity, and exhibits notable inhibition of the Gloeobacter violaceus ligand-gated ion channel. Despite its broad spectrum of activities, it exhibits minimal cytotoxic effects on several cell lines at the tested concentrations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/VEGFR2/c-Met-Akt-NF-κB signaling pathways; this combination may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of lung cancer.
别名	香豆素-3-羧酸, 3-Carboxycoumarin

化学信息

分子量	190.15
分子式	C₁₀H₆O₄
CAS No.	531-81-7
Smiles	OC(=O)C1=CC2=C(OC1=O)C=CC=C2
密度	1.493g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (262.95 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2590 mL	26.2950 mL	52.5901 mL	262.9503 mL
5 mM	1.0518 mL	5.2590 mL	10.5180 mL	52.5901 mL
10 mM	0.5259 mL	2.6295 mL	5.2590 mL	26.2950 mL
20 mM	0.2630 mL	1.3148 mL	2.6295 mL	13.1475 mL
50 mM	0.1052 mL	0.5259 mL	1.0518 mL	5.2590 mL
100 mM	0.0526 mL	0.2630 mL	0.5259 mL	2.6295 mL