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AG126

Name: AG126
Brand: TargetMol
SKU: T4092
Price: 140 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.35%

货号 T4092Cas号 118409-62-4

别名 Tyrphostin AG126, AG 126

AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。

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AG126

一键复制产品信息

很棒

纯度: 97.35%

货号 T4092 别名 Tyrphostin AG126, AG 126Cas号 118409-62-4

AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。

规格	价格	库存
1 mg	¥ 140	现货
5 mg	¥ 347	现货
10 mg	¥ 581	现货
25 mg	¥ 978	现货
50 mg	¥ 1,450	现货
100 mg	¥ 2,130	现货
200 mg	¥ 2,970	现货
1 mL x 10 mM (in DMSO)	¥ 329	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

AG126 AI Summary

AG126 is a versatile bioactive molecule exhibiting significant inhibitory properties across a spectrum of biological targets. As an inhibitor of EGF-dependent autophosphorylation of the epidermal growth factor receptor kinase, it has an IC50 of 450,000.0 nM and a Ki value of 150,000.0 nM, indicating its potency in this specific inhibition process. Additionally, it displays antiplasmodial activity against Plasmodium falciparum 3D7 with an IC50 value of 12,589.25 nM, as measured by the SYBR green assay. Beyond these activities, AG126 shows a broad range of bioactivities including inhibition of HSD17B4, RecQ-Like DNA Helicase 1, Leishmania Mexicana Pyruvate Kinase, JMJD2E, Tyrosyl-DNA Phosphodiesterase (TDP1), tau fibril formation, aldehyde dehydrogenase 1 (ALDH1A1), and Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). It also inhibits the refolding of denatured proteins such as rhodanese and soluble pig heart MDH enzymes with notable efficacy, showing 96.0% inhibition of Escherichia coli GroEL and GroES proteins, as well as 92.0% inhibition of refolding. Furthermore, it has shown activity in assays involving cytochrome P450 enzymes and Marburg Virus entry inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM).
靶点活性	GFRK:> 100 μM, GFRK:450 μM, ERK1 (p44):25-50 μM, ERK2 (p42):25-50 μM
别名	Tyrphostin AG126, AG 126

化学信息

分子量	215.16
分子式	C₁₀H₅N₃O₃
CAS No.	118409-62-4
Smiles	Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O
密度	1.496g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (464.77 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (18.59 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6477 mL	23.2385 mL	46.4770 mL	232.3852 mL
5 mM	0.9295 mL	4.6477 mL	9.2954 mL	46.4770 mL
10 mM	0.4648 mL	2.3239 mL	4.6477 mL	23.2385 mL
20 mM	0.2324 mL	1.1619 mL	2.3239 mL	11.6193 mL
50 mM	0.0930 mL	0.4648 mL	0.9295 mL	4.6477 mL
100 mM	0.0465 mL	0.2324 mL	0.4648 mL	2.3239 mL