Name: ATWLPPR Peptide TFA
Brand: TargetMol
SKU: T10408
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

50 mg

待询

100 mg

待询

生物活性

产品描述	ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes.
体外活性	ATWLPPR Peptide TFA inhibits VEGF165 binding to NRP-1 by 82% at 100 μM [1].
体内活性	ATWLPPR (400 μg/kg, s.c.) preserves vascular integrity and decreases the oxidative stress level, possibly reduces the early retinal damage caused by diabetes. ATWLPPR prevents the increase of inflammation-associated proteins (GFAP, VEGF, and ICAM-1) in the retina [2].

化学信息

分子量	954
分子式	C₄₂H₆₂F₃N₁₁O₁₁
Smiles	O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)[C@H](C)N.OC(C(F)(F)F)=O
密度	no data available

储存&溶解度

存储

溶解度信息

H2O: 50 mg/mL (52.41 mM), Sonication is recommended.

溶液配制表

H2O

ATWLPPR Peptide TFA