Name: Febuxostat Acyl Glucuronide
Brand: TargetMol
SKU: T35621
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

500 μg

¥ 1,410

35日内发货

2500 μg

¥ 6,230

35日内发货

生物活性

产品描述	Febuxostat Acyl Glucuronide is the primary metabolite of the potent xanthine oxidase (XO) inhibitor Febuxostat. It is formed through the glucuronidation of the carboxylic acid group of Febuxostat, a process mediated by UDP-glucuronosyltransferase (UGT) enzymes. The production of this acyl glucuronide is a major elimination pathway for the parent drug. Researching this metabolite is essential for characterizing metabolic clearance, understanding drug-drug interactions, and evaluating the pharmacokinetic variability of Febuxostat across different patient populations, including those with UGT enzymatic polymorphisms.
体外活性	Febuxostat Acyl Glucuronide主要由 UGT1A1、1A3、1A8 及 1A9 代谢生成，其黄嘌呤氧化酶抑制活性极低，证实葡萄糖醛酸化是其主要失活途径。作为一种酰基葡萄糖苷酸，该代谢物在生理 pH 下可发生酰基迁移及与蛋白共价结合，因此常被用于评估潜在的免疫原性或毒理学风险 [1]。
别名	非布司他杂质, Febuxostat acyl-β-D-glucuronide

化学信息

分子量	492.5
分子式	C₂₂H₂₄N₂O₉S
CAS No.	1351692-92-6
Smiles	C(O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O)(=O)C=2SC(=NC2C)C3=CC(C#N)=C(OCC(C)C)C=C3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Methanol: Soluble

DMSO: Soluble

Febuxostat Acyl Glucuronide