CK1-IN-1

Name: CK1-IN-1
Brand: TargetMol
SKU: T5393
Price: 479 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.79%

货号 T5393Cas号 1784751-20-7

别名 PUN51207

CK1-IN-1 (PUN51207) 是一种酪蛋白激酶 1 抑制剂，对 CK1δ、CK1ε和p38σ MAPK 的IC50值为 15 nM、16 nM 和73 nM。

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CK1-IN-1

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很棒

纯度: 98.79%

货号 T5393 别名 PUN51207Cas号 1784751-20-7

CK1-IN-1 (PUN51207) 是一种酪蛋白激酶 1 抑制剂，对 CK1δ、CK1ε和p38σ MAPK 的IC50值为 15 nM、16 nM 和73 nM。

规格	价格	库存
1 mg	¥ 479	现货
5 mg	¥ 993	现货
10 mg	¥ 1,650	现货
25 mg	¥ 3,230	现货
50 mg	¥ 4,970	现货
100 mg	¥ 6,880	现货
200 mg	¥ 9,270	现货
1 mL x 10 mM (in DMSO)	¥ 1,090	现货

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产品介绍

CK1-IN-1 AI Summary

CK1-IN-1 exhibits a range of bioactivities and its effects are highly cell-type dependent. In HEK293T cells, it influences cell proliferation with growth rates between 0.41 and 0.81, suggesting a potential stimulatory effect. In contrast, U2OS cells show a negative growth rate of -1.0, indicating an inhibitory effect. Human fibroblast cells exhibit variable growth rates from -0.01 to 0.8, showing both inhibitory and stimulatory effects on cell viability. In addition to its cell-type-specific effects, CK1-IN-1 also influences protein stability, as evidenced by Thermal Shift Assay results. This compound significantly increases the thermal stability of certain protein domains with Delta TM values ranging from 0.03°C to 8.59°C. Conversely, it can also decrease thermal stability in some protein domains, with negative Delta TM values between -0.5°C and -0.46°C. Thus, CK1-IN-1 demonstrates diverse bioactivities, impacting both cell viability and protein stability in varying contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
靶点活性	CK1ε:16 nM (cell free), CK1δ:15 nM (cell free), p38σ MAPK:73 nM (cell free)
别名	PUN51207

化学信息

分子量	383.39
分子式	C₂₄H₁₅F₂N₃
CAS No.	1784751-20-7
Smiles	Fc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1ccc2ccccc2c1F
密度	1.310 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (156.5 mM), Sonication is recommended.

H2O: Insoluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6083 mL	13.0416 mL	26.0831 mL	130.4155 mL
5 mM	0.5217 mL	2.6083 mL	5.2166 mL	26.0831 mL
10 mM	0.2608 mL	1.3042 mL	2.6083 mL	13.0416 mL
20 mM	0.1304 mL	0.6521 mL	1.3042 mL	6.5208 mL
50 mM	0.0522 mL	0.2608 mL	0.5217 mL	2.6083 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3042 mL