Chlorindione

Name: Chlorindione
Brand: TargetMol
SKU: T0360
Price: 236 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.67%

货号 T0360Cas号 1146-99-2

别名 氯苯茚二酮, Indaliton, G-25766, chlophenadione

Chlorindione (chlophenadione) 是一种维生素 K1 的拮抗剂，也是一种有效的抗凝剂。

Chlorindione

一键复制产品信息

很棒

纯度: 99.67%

货号 T0360 别名 氯苯茚二酮, Indaliton, G-25766, chlophenadioneCas号 1146-99-2

Chlorindione (chlophenadione) 是一种维生素 K1 的拮抗剂，也是一种有效的抗凝剂。

规格	价格	库存
50 mg	¥ 236	现货
100 mg	¥ 413	待询
200 mg	¥ 588	待询
1 mL x 10 mM (in DMSO)	¥ 455	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.67%

联系我们获取更多批次信息

资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

Chlorindione AI Summary

Chlorindione demonstrates a diverse range of bioactivities and pharmacological properties. It inhibits 5-lipoxygenase activity in RBL-1 cells with an IC50 value of 5000.0 nM and shows hypolipidemic effects in CF1 male mice at a dose of 20 mg/kg per day, significantly reducing serum cholesterol levels by 1% on both the 9th and 16th days and decreasing serum triglyceride levels by 47% on the 16th day compared to control. The compound also modulates miRNAs, activates the Rab9 promoter, inhibits influenza NS1 protein function, and affects various other biological targets including Nrf2, G9a, BAZ2B, ELG1-dependent DNA repair, malarial parasite plastid, firefly luciferase, and MBNL1-poly(CUG) RNA binding. Additionally, Chlorindione exhibits uncoupling activity of oxidative phosphorylation in rat liver mitochondria with a log(1/C50) value of 4.2. In terms of antiviral properties, Chlorindione shows inhibition of SARS-CoV-2 induced cytotoxicity in both Caco-2 cells (2.17% inhibition at 10 uM after 48 hours) and VERO-6 cells (0.06% inhibition at 10 uM with an IC50 value > 20000.0 nM). It also inhibits the SARS-CoV-2 3CL-Pro protease with a percentage inhibition of 6.823% at 20 µM. Furthermore, Chlorindione demonstrates inhibitory activity on the human HDAC6 enzyme, achieving an inhibition rate of 18.57% using a commercial peptide substrate but showing a slight negative inhibition of -0.61% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.
别名	氯苯茚二酮, Indaliton, G-25766, chlophenadione

化学信息

分子量	256.68
分子式	C₁₅H₉ClO₂
CAS No.	1146-99-2
Smiles	Clc1ccc(cc1)C1C(=O)c2ccccc2C1=O
密度	1.2053 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (194.8 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.79 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8959 mL	19.4795 mL	38.9590 mL	194.7951 mL
5 mM	0.7792 mL	3.8959 mL	7.7918 mL	38.9590 mL
10 mM	0.3896 mL	1.9480 mL	3.8959 mL	19.4795 mL
20 mM	0.1948 mL	0.9740 mL	1.9480 mL	9.7398 mL
50 mM	0.0779 mL	0.3896 mL	0.7792 mL	3.8959 mL
100 mM	0.0390 mL	0.1948 mL	0.3896 mL	1.9480 mL