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别名 皮米伐利尤单抗, JTX-4014
Pimivalimab (JTX-4014) 是一种高亲和力的全人源 IgG4 单克隆抗体,靶向细胞表面受体 PD-1。该抗体通过阻断 PD-1 与其配体 PD-L1 和 PD-L2 的相互作用,能够逆转 T 细胞的免疫抑制状态并增强机体对多种实体瘤的抗肿瘤免疫应答。常作为单药或与 LILRB2 抑制剂等其他疗法联用进行研究。
Pimivalimab (JTX-4014) 是一种高亲和力的全人源 IgG4 单克隆抗体,靶向细胞表面受体 PD-1。该抗体通过阻断 PD-1 与其配体 PD-L1 和 PD-L2 的相互作用,能够逆转 T 细胞的免疫抑制状态并增强机体对多种实体瘤的抗肿瘤免疫应答。常作为单药或与 LILRB2 抑制剂等其他疗法联用进行研究。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | 待询 | 待询 |
| 产品描述 | Pimivalimab (JTX-4014) is a high-affinity, fully human IgG4 monoclonal antibody targeting the cell surface receptor PD-1. By blocking the interaction between PD-1 and its ligands PD-L1 and PD-L2, the antibody reverses the immunosuppressed state of T cells and enhances the anti-tumor immune response against various solid tumors. It is frequently studied as a monotherapy or in combination with other therapies, such as LILRB2 inhibitors. |
| 别名 | 皮米伐利尤单抗, JTX-4014 |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG4 (S228P) |
| 推荐同型对照 |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | PD-1 |
| CAS No. | 2293951-22-9 |
| 存储 | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.(实际储存温度请以该批次产品标识为准) |
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