规格

价格

库存

数量

5 mg

¥ 661

1-2周

50 mg

¥ 1,990

1-2周

100 mg

¥ 2,820

1-2周

生物活性

产品描述	MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.
体外活性	MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].
体内活性	cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively. The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg) [4].
别名	Monomethylauristatin F Hydrochloride

化学信息

分子量	768.42
分子式	C₃₉H₆₆ClN₅O₈
CAS No.	1415246-68-2
Smiles	Cl.[H][C@](NC(=O)[C@@H](NC)C(C)C)(C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)OC
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27 mg/mL (35.14 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (2.6 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO