keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
aliotoxin是神经BK型肽基的抑制剂,对Kv通道和钙激活的钾通道能产生特异性抑制。Kaliotoxin对细胞膜电位和神经元兴奋性的调控具有研究意义。其产品编号为 T37808,CAS号为 145199-73-1
产品描述 | Kaliotoxin is an inhibitor of neuronal BK-type peptide groups and specifically inhibits Kv channels and calcium-activated potassium channels. Kaliotoxin has research significance on the regulation of cell membrane potential and neuronal excitability. The product number is T37808 and the CAS number is 145199-73-1 |
体外活性 | Kaliotoxin (250 nM) specifically inhibited the overall Ca2+-activated K+ current in the entire cell. The interaction between Kaliotoxin and KCa channels follows a one-to-one way mechanism with Kd of 20 nM.[1] |
体内活性 | Kaliotoxin (10 ng; Male Sprague–Dawley rats; Intracerebroventricular injection) facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels. Improved learning but not information consolidation. Increased the long-term retrieval of an odor-reward association.[2] |
分子量 | 4149.94 |
分子式 | C171H283N55O49S8 |
CAS No. | 145199-73-1 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Kaliotoxin 145199-73-1 Inhibitor inhibitor inhibit