Name: CZL80
Brand: TargetMol
SKU: T86155
Price: 248 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 248

现货

5 mg

¥ 579

现货

10 mg

¥ 928

现货

25 mg

¥ 1,850

现货

50 mg

¥ 2,980

现货

100 mg

¥ 4,770

现货

1 mL x 10 mM (in DMSO)

¥ 637

现货

生物活性

产品描述	CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
靶点活性	Caspase-1:0.01 μM
体内活性	CZL80 (10、30 mg/kg/天，腹腔注射，持续7天）改善了C57BL/6小鼠与Caspase-1⁻/⁻小鼠光血栓性脑卒中后的运动功能障碍 [2]。 CZL80 (0.0075、0.075、0.75和7.5 mg/kg，静脉注射，隔日给药）以剂量依赖性方式降低Casp1⁻/⁻小鼠癫痫发作发生率、延长癫痫发作潜伏期，并提高热性惊厥的诱发阈值 [1]。
别名	CZL-80, CZL 80

化学信息

分子量	366.39
分子式	C₁₉H₁₄N₂O₄S
CAS No.	313482-91-6
Smiles	O=C(O)C=1C=CC=C(C1)NC(=O)C=2C=CC=C(C2)NC(=O)C=3SC=CC3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度信息	DMSO: ≥ 160 mg/mL, Sonication is recommended.

CZL80