Dotinurad

Name: Dotinurad
Brand: TargetMol
SKU: T15160
Price: 972 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.04%

货号 T15160Cas号 1285572-51-1

别名 (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) 是有效的尿酸盐重吸收选择性抑制剂，抑制尿酸盐转运蛋白 1的IC50为 37.2 nM，具有促尿酸排泄的作用。

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Dotinurad

一键复制产品信息

很棒

纯度: 98.04%

货号 T15160 别名 (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanoneCas号 1285572-51-1

规格	价格	库存
1 mg	¥ 972	现货
5 mg	¥ 2,430	现货
10 mg	¥ 3,590	现货
25 mg	¥ 5,750	现货
50 mg	¥ 7,770	现货
100 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 2,430	现货

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产品介绍

Dotinurad AI Summary

Dotinurad is a multifaceted bioactive agent with diverse interactions and pharmacokinetics. It inhibits uricase1 with an IC50 of 3600.0 nM and exhibits strong inhibition of human URAT1, particularly in Xenopus laevis oocytes, with an IC50 of 37.2 nM and an inhibition percentage of 78.0% at 0.1 μM. Additionally, it inhibits URAT1 in human RPTEC, achieving an IC50 of 6800.0 nM and 81.0% inhibition at 10 μM concentration. In Cebus monkeys, it shows a uricosuric effect with an activity of 16.5%. The compound is hepatotoxic to rat liver mitochondria, with an IC50 of 27000.0 nM, and inhibits CYP2C9 with an IC50 of 5700.0 nM. Pharmacokinetic studies reveal it achieves a Cmax of 25516.47 nM in rats when administered orally at 3 mg/kg, with a 1.1% excretion rate in rat urine over 4 hours. In drug metabolism studies, Dotinurad shows significant metabolism in rat plasma (81.9%), cynomolgus monkey plasma (92.0%), and human plasma (80.9%). The compound also demonstrates excretion in human urine, with 44.3% as the glucuronide metabolite and 20.0% as the sulfate metabolite of phenols. These attributes underscore the compound's potent inhibitory effects and efficient metabolic profile across different species..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).
靶点活性	URAT1:37.2nM
别名	(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

化学信息

分子量	358.2
分子式	C₁₄H₉Cl₂NO₄S
CAS No.	1285572-51-1
Smiles	C(=O)(N1C=2C(S(=O)(=O)C1)=CC=CC2)C3=CC(Cl)=C(O)C(Cl)=C3
密度	1.662 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (167.5 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7917 mL	13.9587 mL	27.9174 mL	139.5868 mL
5 mM	0.5583 mL	2.7917 mL	5.5835 mL	27.9174 mL
10 mM	0.2792 mL	1.3959 mL	2.7917 mL	13.9587 mL
20 mM	0.1396 mL	0.6979 mL	1.3959 mL	6.9793 mL
50 mM	0.0558 mL	0.2792 mL	0.5583 mL	2.7917 mL
100 mM	0.0279 mL	0.1396 mL	0.2792 mL	1.3959 mL