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Edoxudine

Name: Edoxudine
Brand: TargetMol
SKU: T4374
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T4374Cas号 15176-29-1

别名 乙去氧尿啶, 依度尿苷, EUDR, Epoxudine, Aedurid

Edoxudine (Epoxudine) 是胸苷的类似物，是一种抗病毒药物，对单纯疱疹病毒有效。

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Edoxudine

一键复制产品信息

很棒

纯度: 99.94%

货号 T4374 别名 乙去氧尿啶, 依度尿苷, EUDR, Epoxudine, AeduridCas号 15176-29-1

Edoxudine (Epoxudine) 是胸苷的类似物，是一种抗病毒药物，对单纯疱疹病毒有效。

规格	价格	库存
1 mg	¥ 123	现货
5 mg	¥ 255	现货
10 mg	¥ 413	现货
25 mg	¥ 815	现货
50 mg	¥ 1,320	现货
100 mg	¥ 2,150	现货
200 mg	¥ 3,190	现货
1 mL x 10 mM (in DMSO)	¥ 279	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.94%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Edoxudine AI Summary

Edoxudine exhibits potent antiviral activity against various strains of herpes simplex virus (HSV-1 and HSV-2) with increasing inhibition rates as the concentration increases, achieving up to 100% inhibition at specific concentrations. It reduces plaque formation significantly in human embryonic lung fibroblast (HELF) and vero cells, with ID50 values ranging between 10.0 µM and 40.0 µM and MIC50 values from 20.0 µg/mL to 140000.0 nM. Notably, it also demonstrates low cytotoxicity in HELF, human foreskin fibroblast cells, and African green monkey Vero cells, with CC50 values greater than 780000.0 nM and 200.0 µg/mL. Furthermore, compound 169382 possesses selective antiviral effects against a broader range of viruses, including vaccinia virus, varicella-zoster virus (VZV), and Epstein-Barr virus (EBV), exhibiting EC50 values from 600.0 nM to 66400.0 nM. Against Mycobacterium tuberculosis, it shows inhibitory activity on thymidine monophosphate kinase (TMPK) with a Ki value of 1140000.0 nM. The compound also demonstrates cytostatic activity against L1210/0 and Raji/0 cells with ID50 values of 1.6 and 2.9 µg/mL respectively. Edoxudine's antiviral properties extend to SARS-CoV-2, where it prevents virus-induced cytotoxicity in Caco-2 and VERO-6 cells, although its potency remains relatively low with observed IC50 values greater than 100000.0 nM. It has been tested as a 3CL-Pro protease inhibitor for SARS-CoV-2, showing partial inhibition at 20 µM. In addition, it inhibits DNA repair enzymes, sodium fluorescein uptake in OATP-transfected CHO cells, and displays moderate cytotoxicity against select human cell lines, supporting its potential therapeutic implications in viral infection control and enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels. It can also enhance the antitumour action of 5-FU.

别名

乙去氧尿啶, 依度尿苷, EUDR, Epoxudine, Aedurid

化学信息

分子量	256.26
分子式	C₁₁H₁₆N₂O₅
CAS No.	15176-29-1
Smiles	CCc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O
密度	1.389 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (175.6 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.8 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9023 mL	19.5114 mL	39.0229 mL	195.1143 mL
5 mM	0.7805 mL	3.9023 mL	7.8046 mL	39.0229 mL
10 mM	0.3902 mL	1.9511 mL	3.9023 mL	19.5114 mL
20 mM	0.1951 mL	0.9756 mL	1.9511 mL	9.7557 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9023 mL
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9511 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。