11R-VIVIT

Name: 11R-VIVIT
Brand: TargetMol
SKU: TP1978
Rating: 4.5 (1 reviews)

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货号 TP1978Cas号 592517-80-1

别名 NFAT inhibitor, Cell Permeable

NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.

11R-VIVIT

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货号 TP1978 别名 NFAT inhibitor, Cell PermeableCas号 592517-80-1

规格	价格	库存	数量
1 mg	¥ 9,480	35日内发货

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生物活性

产品描述	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.
别名	NFAT inhibitor, Cell Permeable

化学信息

分子量	3573.15
分子式	C₁₄₇H₂₅₉N₆₇O₃₆S
CAS No.	592517-80-1
Smiles	C([C@@H](NC(=O)[C@H]1N(C(CNC([C@@H](NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)=O)=O)CCSC)=O)C)=O)=O)CCC1)CC2=CN=CN2)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(=O)N4[C@H](C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCC(O)=O)=O)=O)CCC4)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)C(C)C)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CCC3
密度	1.56 g/cm3 (Predicted)
Sequence Short	RRRRRRRRRRRGGGMAGPHPVIVITGPHEE

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 1 mg/mL (0.28 mM), Sonication is recommended.