购物车
您的购物车当前为空
PF-4840154
一键复制产品信息
很棒货号 T4385Cas号 1332708-14-1
PF4840154 是有效的大鼠和人TrpA1通道选择性激动剂，EC50分别为 97 和 23 nM。PF-4840154 可以诱导 TrpA1 介导的小鼠伤害行为。
为众多的药物研发团队赋能，
让新药发现更简单！
PF-4840154
一键复制产品信息 很棒货号 T4385Cas号 1332708-14-1
PF4840154 是有效的大鼠和人TrpA1通道选择性激动剂，EC50分别为 97 和 23 nM。PF-4840154 可以诱导 TrpA1 介导的小鼠伤害行为。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 745 | 现货 | |
| 5 mg | ¥ 1,650 | 现货 | |
| 10 mg | ¥ 2,650 | 现货 | |
| 25 mg | ¥ 4,270 | 现货 | |
| 50 mg | ¥ 5,930 | 现货 | |
| 100 mg | ¥ 8,150 | 待询 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,120 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
PF-4840154 AI Summary
PF-4840154 exhibits various bioactivities including inhibitory effects on the noradrenaline transporter, dopamine transporter, chloride channel, dopamine D3 receptor, and sigma receptor, all with inhibition levels below 10.0%. The compound also shows inhibition of human ERG with an IC50 of 580.0 nM and demonstrates good aqueous solubility at 6400.0 nM. Additionally, PF-4840154 acts as an agonist at the human TRPA1 channel with an EC50 of 23.0 nM and at the rat TRPA1 channel with an EC50 of 97.0 nM, as assessed by calcium influx measurements.
The compound has intrinsic clearance values in both rat hepatocytes and human liver microsomes. In rat hepatocytes, the intrinsic clearance ranges from <3 to >150 microL/min/1E6 cells, with a measured value of 89.13 microL.min-1.(10^6 cells)-1. In human liver microsomes, the clearance ranges from <3 to >150 microL/min/mg with a specific value of 95.5 mL.min-1.g-1.
In cell viability assays, PF-4840154 exhibits varying effects: it promotes growth in HEK293T cells with growth rate values ranging from 0.68 to 0.95, and in U2OS cells with values ranging from 0.3 to 0.99. Conversely, it negatively impacts the growth rate of human fibroblast cells, with values ranging from -0.64 to -1.0. These results indicate that PF-4840154 may have cell-type-specific effects, which could have significant implications for its bioactivity..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. |
| 靶点活性 | TRPA1 (rat):97 nM, TRPA1 (human):23 nM |
| 分子量 | 466.62 |
| 分子式 | C26H38N6O2 |
| CAS No. | 1332708-14-1 |
| Smiles | CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1 |
| 密度 | 1.164 g/cm3 (Predicted) |
| 颜色 | White |
| 物理性状 | solid |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 4.67 mg/mL (10.01 mM), Sonication is recommended. | ||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.14 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy PF-4840154 | purchase PF-4840154 | PF-4840154 cost | order PF-4840154 | PF-4840154 chemical structure | PF-4840154 formula | PF-4840154 molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441