lutidinic acid

Name: lutidinic acid
Brand: TargetMol
SKU: T2167
Price: 150 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.06%

货号 T2167Cas号 499-80-9

别名 卢剔啶酸, 2,4-Pyridinedicarboxylic acid, 2,4-PDCA, 2,4-Dicarboxypyridine, 2, 4-PDCA

lutidinic acid (2,4-Dicarboxypyridine) 是一种体外和细胞内抑制剂，也是一种已知的组蛋白赖氨酸脱甲基酶抑制剂。

lutidinic acid

一键复制产品信息

很棒

纯度: 98.06%

货号 T2167 别名 卢剔啶酸, 2,4-Pyridinedicarboxylic acid, 2,4-PDCA, 2,4-Dicarboxypyridine, 2, 4-PDCACas号 499-80-9

lutidinic acid (2,4-Dicarboxypyridine) 是一种体外和细胞内抑制剂，也是一种已知的组蛋白赖氨酸脱甲基酶抑制剂。

规格	价格	库存
50 mg	¥ 258	现货
100 mg	¥ 413	现货
200 mg	¥ 588	现货
1 mL x 10 mM (in DMSO)	¥ 150	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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纯度: 98.06%

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产品介绍

lutidinic acid AI Summary

lutidinic acid exhibits a broad spectrum of bioactivity, demonstrating significant inhibition across various enzymes, proteins, and biological processes. It showcases an inhibitory effect against vesicular glutamate transport in synaptic vesicles from rat forebrain, achieving 92.0% activity. Additionally, it targets multiple metallo beta-lactamases such as IMP1, VIM2, and FEZ1, with inhibition rates ranging from 65.0% to 98.0%. The compound also impacts several human enzymes, including the 2-oxoglutarate-dependent JMJD2E enzyme (IC50: 4700.0 to 1400.0 nM), human collagen prolyl-4-hydroxylase (Ki: 2000.0 nM), and PHD2 enzyme (IC50: 2000.0 to 1910.0 nM). It modulates epigenetic regulation by affecting KDM4C (IC50: 19.0 nM), JMJD2A (IC50: 700.0 nM), and KDM5B catalytic core (IC50: 3000.0 nM). In addition, it has shown antiviral activity by inhibiting the SARS-CoV-2 3CL-Pro protease by 19.55% at 20 µM. The compound demonstrates diverse inhibitory effects, including against FIH (IC50: 1100.0 nM), ALDH1A1 (IC50: 1412.5 nM), and ALKBH5 (IC50: 9430.0 nM), suggesting potential therapeutic applications across various biological pathways and conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
别名	卢剔啶酸, 2,4-Pyridinedicarboxylic acid, 2,4-PDCA, 2,4-Dicarboxypyridine, 2, 4-PDCA

化学信息

分子量	167.12
分子式	C₇H₅NO₄
CAS No.	499-80-9
Smiles	C(O)(=O)C=1C=C(C(O)=O)N=CC1
密度	1.551 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (179.51 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.97 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9837 mL	29.9186 mL	59.8372 mL	299.1862 mL
5 mM	1.1967 mL	5.9837 mL	11.9674 mL	59.8372 mL
10 mM	0.5984 mL	2.9919 mL	5.9837 mL	29.9186 mL
20 mM	0.2992 mL	1.4959 mL	2.9919 mL	14.9593 mL
50 mM	0.1197 mL	0.5984 mL	1.1967 mL	5.9837 mL
100 mM	0.0598 mL	0.2992 mL	0.5984 mL	2.9919 mL