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Otenaproxesul

Name: Otenaproxesul
Brand: TargetMol
SKU: T1867
Price: 248 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.13%

货号 T1867Cas号 1226895-20-0

别名 ATB 346

Otenaproxesul (ATB 346) 是一种具有口服活性的非甾体抗炎药，可抑制环氧合酶-1 和 2，具有抗炎生物活性，可用于缓解疼痛的研究。

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Otenaproxesul

一键复制产品信息

很棒

纯度: 99.13%

货号 T1867 别名 ATB 346Cas号 1226895-20-0

Otenaproxesul (ATB 346) 是一种具有口服活性的非甾体抗炎药，可抑制环氧合酶-1 和 2，具有抗炎生物活性，可用于缓解疼痛的研究。

规格	价格	库存
1 mg	¥ 248	现货
5 mg	¥ 578	现货
10 mg	¥ 892	现货
25 mg	¥ 1,790	现货
50 mg	¥ 2,690	现货
100 mg	¥ 3,930	现货
200 mg	¥ 5,530	现货
1 mL x 10 mM (in DMSO)	¥ 465	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Otenaproxesul AI Summary

Otenaproxesul demonstrates a range of bioactivities including rapid degradation in phosphate buffer with a half-life of 0.2233 hours and a high H2S Cmax of 23500.0 nM. It exhibits cytotoxicity against various cell lines, with an IC50 value of 227600.0 nM for human HepG2 cells and 3614900.0 nM for human LO2 cells. In mouse RAW264.7 cells, it shows cytotoxic activity less than or equal to 70.0% regardless of LPS induction and induces HO-1 expression with a fold change of less than or equal to 2.0 compared to control, indicating anti-inflammatory activity. The compound also displays antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 9.93% at 10 µM after 48 hours, and shows 5.162% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. Additionally, it inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 0.05% at the same concentration and time. Furthermore, Otenaproxesul exhibits potential as an HDAC6 inhibitor, with 29.0% inhibition using a commercial peptide substrate and 7.55% inhibition using a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
别名	ATB 346

化学信息

分子量	365.45
分子式	C₂₁H₁₉NO₃S
CAS No.	1226895-20-0
Smiles	COc1ccc2cc(ccc2c1)C(C)C(=O)Oc1ccc(cc1)C(N)=S
密度	1.261 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (136.82 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.47 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7364 mL	13.6818 mL	27.3635 mL	136.8176 mL
5 mM	0.5473 mL	2.7364 mL	5.4727 mL	27.3635 mL
10 mM	0.2736 mL	1.3682 mL	2.7364 mL	13.6818 mL
20 mM	0.1368 mL	0.6841 mL	1.3682 mL	6.8409 mL
50 mM	0.0547 mL	0.2736 mL	0.5473 mL	2.7364 mL
100 mM	0.0274 mL	0.1368 mL	0.2736 mL	1.3682 mL