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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Sanguinarine chloride

Synonyms: 血根碱, 氯化血根碱, Sanguinarium chloride, Pseudochelerythrine chloride
货号 T0129Cas号 5578-73-4 一键复制产品信息纯度: 99.41%
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Sanguinarine chloride (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱，通过激活活性氧的产生，诱导细胞凋亡。

Sanguinarine chloride

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纯度: 99.41%

货号 T0129Cas号 5578-73-4

别名 血根碱, 氯化血根碱, Sanguinarium chloride, Pseudochelerythrine chloride

Sanguinarine chloride (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱，通过激活活性氧的产生，诱导细胞凋亡。

Sanguinarine chloride
其他形式的 “Sanguinarine chloride”:
Sanguinarine citrate
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规格价格库存数量
20 mg
¥ 190
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纯度: 99.41%
资源下载: COA HNMR HPLC LCMS产品操作手册

产品介绍

Sanguinarine chloride AI Summary
Sanguinarine chloride exhibits a broad spectrum of bioactivities, demonstrating both inhibitory and cytotoxic effects across various biological systems. It inhibits MRP2-mediated transport of estradiol-17-beta-glucuronide in Sf9 cell membrane vesicles with an activity of 44.0% compared to control. In cancer cell studies, it inhibits the growth of HeLa S3 cells with an IC50 of 0.16 µg/mL and shows significant antitumor activity against mouse P388 xenografts at dosages of 12.5 mg/kg, 25 mg/kg, and 50 mg/kg. However, high dosages also result in toxicity, reducing the mean survival duration in treated mice. In biochemical assays, Sanguinarine chloride inhibits Rac GTPase activation in Rac1b overexpressing HEK293 cells with an IC50 of 4600.0 nM, showing selective inhibition towards Rac1 over Rac1b and also inhibits Cdc42 GTPase activity (IC50 of 32000.0 nM). It demonstrates anti-malarial activity against different strains of Plasmodium falciparum with IC50 values between 2511.89 nM and 6309.57 nM. Additionally, it shows antibacterial activity against various bacterial strains, including vancomycin-resistant and sensitive Enterococcus faecalis and Staphylococcus aureus, with varying MIC values. The compound has antiviral properties, reducing SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM. It also inhibits SARS-CoV-2 3CL-Pro protease by 73.66% at 20 µM and MERS 3CL-Pro protease by 32.0% at 10 µM. In terms of GTPase signaling modulation, Sanguinarine chloride inhibits RGS17 with an IC50 of 12520.0 nM and binds to RGS17 with a Kd of 1020.0 nM. It shows antiproliferative effects in A549, H1975, and HeLa cells, with IC50 values of 1590.0 nM, 1320.0 nM, and 2430.0 nM respectively. Lastly, Sanguinarine chloride inhibits Mycobacterium tuberculosis PptT in Escherichia coli with an IC50 of 4900.0 nM and demonstrates antimycobacterial activity with a MIC of 24.5 µg/mL. Overall, Sanguinarine chloride displays a diverse range of bioactivities, making it a potential candidate for further pharmaceutical development..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen species (ROS).
靶点活性
PP2C:0.68 μM(Ki)
别名
血根碱, 氯化血根碱, Sanguinarium chloride, Pseudochelerythrine chloride
化学信息
分子量367.78
分子式C20H14ClNO4
CAS No.5578-73-4
Smiles[Cl-].C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
密度no data available
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO: 2.16 mg/mL (5.87 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.7190 mL13.5951 mL27.1902 mL135.9508 mL
5 mM0.5438 mL2.7190 mL5.4380 mL27.1902 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

VEGFRSanguinarium ChlorideSanguinariumSanguinarine ChlorideSanguinarineSanguinarinPseudochelerythrine ChloridePseudochelerythrineParasiteInhibitorinhibitEgr-1BacterialAutophagyApoptosis
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