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MF-438

Name: MF-438
Brand: TargetMol
SKU: T16068
Price: 867 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.50%

货号 T16068Cas号 921605-87-0

MF-438 是一种口服具有活力的 stearoyl-CoA desaturase 1 抑制剂，其对 rSCD1 的 EC50值为 2.3 nM。

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MF-438

一键复制产品信息

很棒

纯度: 99.50%

货号 T16068Cas号 921605-87-0

MF-438 是一种口服具有活力的 stearoyl-CoA desaturase 1 抑制剂，其对 rSCD1 的 EC50值为 2.3 nM。

规格	价格	库存
1 mg	¥ 867	现货
5 mg	¥ 1,860	现货
10 mg	¥ 2,830	现货
25 mg	¥ 4,590	现货
50 mg	¥ 6,460	现货
100 mg	¥ 8,690	现货
200 mg	¥ 11,700	现货
1 mL x 10 mM (in DMSO)	¥ 1,720	现货

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COA HPLC HNMR LCMS 产品操作手册

产品介绍

MF-438 AI Summary

MF-438 has demonstrated significant oral bioavailability in preclinical models, with 73.0% in mice and 38.0% in rats. It features a moderate half-life of roughly 6 hours in both species. This compound exhibits potent inhibitory activity against stearoyl-CoA desaturase 1 (SCD1), with an IC50 value of 2.3 nM in rat liver microsomes and an ED50 of 1.0 mg/kg in high-carbohydrate diet-fed mice for inhibiting the conversion of [14C]stearic acid to [14C]oleic acid. Additionally, MF-438 shows antidiabetic properties in diet-induced obese C57BL6 mice, improving glucose clearance with an ED50 ranging from 3.0 to 75.0 mg/kg, and modulates lipid metabolism. Its inhibition of SCD activity spans various models, with IC50 values ranging from 2.0 to 157.0 nM, and it demonstrates favorable pharmacokinetic properties with high liver uptake correlate to plasma levels. The compound also impacts body weight gain in diet-induced obese mice. Overall, MF-438 holds potential for therapeutic applications in diabetes and lipid metabolism disorders through effective SCD inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
靶点活性	SCD1 (rat):2.3 nM (EC50)

化学信息

分子量	421.44
分子式	C₁₉H₁₈F₃N₅OS
CAS No.	921605-87-0
Smiles	Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
密度	1.365 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (106.78 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.37 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3728 mL	11.8641 mL	23.7282 mL	118.6409 mL
5 mM	0.4746 mL	2.3728 mL	4.7456 mL	23.7282 mL
10 mM	0.2373 mL	1.1864 mL	2.3728 mL	11.8641 mL
20 mM	0.1186 mL	0.5932 mL	1.1864 mL	5.9320 mL
50 mM	0.0475 mL	0.2373 mL	0.4746 mL	2.3728 mL
100 mM	0.0237 mL	0.1186 mL	0.2373 mL	1.1864 mL