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顶部相关产品产品介绍化学信息储存和溶解信息TCMIP相关数据计算器

Pyrogallol

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纯度: 99.91%

货号 T3749Cas号 87-66-1

别名 连苯三酚, 焦榈酚, Piral, 1,2,3-trihydroxybenzene

Pyrogallol (Piral) 是一种通过加热没食子酸制备的强还原剂，能产生自由基。它是一种具有抗真菌和抗牛皮癣活性的多酚。

Pyrogallol
其他形式的 “Pyrogallol”:
Pyrogallol (Standard)
Pyrogallol triacetate

Pyrogallol

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Rating icon 很棒

纯度: 99.91%

货号 T3749 别名 连苯三酚, 焦榈酚, Piral, 1,2,3-trihydroxybenzeneCas号 87-66-1

Pyrogallol (Piral) 是一种通过加热没食子酸制备的强还原剂，能产生自由基。它是一种具有抗真菌和抗牛皮癣活性的多酚。

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5 g
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纯度: 99.91%
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产品介绍

Pyrogallol AI Summary
Pyrogallol exhibits a wide range of bioactivities across various biological assays. It demonstrates in vitro antimalarial activity against Plasmodium falciparum with an IC50 value of 5660.0 nM and antibacterial activity against Staphylococcus epidermidis and Staphylococcus aureus with EC50 values of 990.0 nM and 490.0 nM, respectively. It acts as an antagonist at the LuxP receptor in Vibrio harveyi MM32, inhibiting autoinducer-2-mediated quorum sensing with an IC50 value of 2000.0 nM. Additionally, it shows quorum sensing inhibition-regulated bioluminescence in Vibrio harveyi with the same IC50. The compound exhibits antioxidant potential with several different measures, including an EC50 of 4200.0 nM in DPPH scavenging assays and an activity level of 0.12 /uM/s. It inhibits COX2 by 57.0% at 100 uM concentration and has an IC50 value of 144000.0 nM for the same enzyme. Additionally, it displays peroxidant property with a ratio of 1.38 and significant inhibition of COX2. Pyrogallol also shows substantial inhibition of rat intestinal sucrase with an IC50 greater than 500000.0 nM and inhibition rate of 42.0% at 500uM concentration. It has a partition coefficient of LogP 1.19 and demonstrates inhibitory activity against various enzymes, including Aldehyde Dehydrogenase 1 (ALDH1A1), Hydroxyacyl-Coenzyme A Dehydrogenase Type II (HADH2), and several others involved in metabolic and signaling pathways. It exhibits antifungal activity with minimum inhibitory concentrations (MICs) ranging from 12.5 ug/mL to >250.0 ug/mL against several fungal pathogens including Epidermophyton floccosum and Cryptococcus neoformans. For selectin inhibition, it demonstrates capacity to hinder cell attachment with varying degrees of inhibition for E-selectin, P-selectin, and L-selectin. It also acts as an enzyme inhibitor for carbonic anhydrase (CA) enzymes with inhibition constants (Ki) ranging from 520.0 nM to 7410.0 nM for different CA isoforms. Further, the compound has shown bioactivity as an inhibitor for enzymes like MMPs involved in extracellular matrix degradation and shows antiviral activity against SARS-CoV-2 with an IC50 greater than 20000.0 nM, indicating some, though not high, antiviral potential. Lastly, it manifests a significant inhibitory effect on various other enzymes and receptors, contributing to its capacity for impacting multiple physiological functions, including liver, kidney, and blood parameters. Overall, Pyrogallol showcases a comprehensive spectrum of bioactivities with varied potencies across different assays..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Pyrogallol (Piral) is a white crystalline powder and a powerful reducing agent prepared by heating gallic acid.
别名连苯三酚, 焦榈酚, Piral, 1,2,3-trihydroxybenzene
化学信息
分子量126.11
分子式C6H6O3
CAS No.87-66-1
SmilesOC1=CC=CC(O)=C1O
密度1.112 g/cm3 at 25℃ (lit.)
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 60.00 mg/mL (475.78 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (15.86 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM7.9296 mL39.6479 mL79.2959 mL396.4793 mL
5 mM1.5859 mL7.9296 mL15.8592 mL79.2959 mL
10 mM0.7930 mL3.9648 mL7.9296 mL39.6479 mL
20 mM0.3965 mL1.9824 mL3.9648 mL19.8240 mL
50 mM0.1586 mL0.7930 mL1.5859 mL7.9296 mL
100 mM0.0793 mL0.3965 mL0.7930 mL3.9648 mL

TCMIP相关数据

中药材来源及性味归经
中药材名称中药材拉丁名性味归经
千金子Euphorbia lathyris L.温辛肝, 肾, 大肠
所属中成药
中成药名称处方组成中成药类型
癫痫宁片马蹄香,牵牛子,钩藤,石菖蒲,甘松,千金子,薄荷脑,缬草化痰药
外用紫金锭山慈菇,朱砂,五倍子,雄黄,红大戟,穿心莲,千金子,三七,冰片,丁香罗勒油疮疡消药
所属中药方剂
方剂名称处方组成剂型处方来源
换金丹广木香,青皮,芦荟,肉豆蔻,麦芽,神曲,山楂,千金子,白术,黄连,槟榔,沉香丸剂《玉案》卷五。
太乙神丹雄黄,文蛤,山慈姑,大戟,千金子,朱砂,麝香散剂《丹溪心法附余》卷二十四。
四虫丹芙蓉叶,紫花地丁,千金子,蛴螬,桑,生姜,大蒜,葱汁散剂《种福堂方》卷四。
椒目丸4花椒,甘遂,附子,千金子,郁李仁,黑牵牛,五灵脂,吴茱萸,当归,延胡索,芫花,地胆,斑蝥,白矾,石膏丸剂《杂病源流犀烛》卷五。
卫生宝丹山慈姑,文蛤,大戟,千金子,麝香,牛黄,珍珠,雄黄,钟乳石,没药,朱砂,琥珀,丁香,沉香,金箔锭剂《惠直堂方》卷一。
千金散2千金子,枳实,青皮,陈皮,香附,山楂,木香,砂仁,白术,沉香散剂《惠直堂方》卷二。
太乙救苦辟瘟丹麻黄,紫苏,山慈姑,五倍子,香附,苍术,半夏,木香,山豆根,丹参,鬼箭羽,辰砂,千金子,大戟,雌黄,细辛,川乌,滑石,麝香,升麻,桔梗,广藿香,陈皮,银花,大黄搽剂《理瀹》。
青黛丸4千金子,轻粉,青黛丸剂《杂病源流犀烛》卷十四。
经验蟾酥五疳丸南木香,青皮,肉豆蔻,芦荟,麦芽,神曲,山楂,千金子,蟾蜍,白术,黄连,槟榔丸剂《医便》卷五引陶国佐方。
赤金锭麻黄,紫苏,山慈姑,五倍子,香附,苍术,半夏,木香,山豆根,丹参,鬼箭羽,朱砂,千金子,大戟,雌黄,细辛,川乌,滑石,麝香锭剂《仙拈集》卷四。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

PyrogallolInhibitorinhibitFungalEndogenousMetaboliteEndogenous MetaboliteApoptosis
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