Name: CGP-53153
Brand: TargetMol
SKU: T10780
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

2-4周

50 mg

¥ 13,800

2-4周

100 mg

¥ 17,500

2-4周

生物活性

产品描述	CGP-53153 is a steroidal inhibitor of 5 alpha-reductase (IC50s: 36 and 262 nM in rat and human prostatic tissue).
靶点活性	5α reductase (rat):36 nM , 5α reductase (human):262 nM
体外活性	CGP-53153 competitively inhibits rat microsomal 5 alpha-reductase from the prostate (IC50: 36 nM) compared to the reference compound finasteride (IC50: 11 nM).
体内活性	CGP-53153 (0.01 mg/kg, p.o.) can significantly reduce T-propionate-mediated prostate growth. CGP-53153 significantly reduces prostate weight at 3 and 10 mg/kg by 31% and 37%, respectively. Treatment for 12 weeks with both CGP-53153 reduces prostate volume by more than 70% in individual dogs. Neither body weight nor the weight of any organ tested is affected by CGP-53153.

化学信息

分子量	383.53
分子式	C₂₃H₃₃N₃O₂
CAS No.	149281-19-6
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC(C#N)(C)C)=O)[H]
密度	1.118 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

CGP-53153