生物活性

产品描述	Pilocarpine Hydrochloride (NSC 5746 HCl) is an M3-type muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride was used to make an experimental model of epilepsy.
靶点活性	Pentoxyresorufin O-dealkylas (mouse liver microsomes):4 μM, Astrocytes:31.86 mM, Testosterone 15 alpha-hydroxylase (mouse liver microsomes):6 μM, CYP2A6 (human liver microsomes):5.31μM, Coumarin 7-hydroxylase (mouse liver microsomes):6 μM, dimethylnitrosamine N-demethylase (mouse liver microsomes):100 μM, testosterone 6 beta-hydroxylase (mouse liver microsomes):> 1 mM, dimethylnitrosamine N-demethylase (human liver microsomes):10 μM, coumarin 7-hydroxylase (human liver microsomes):6 μM
体内活性	方法：为研究Pilocarpine Hydrochloride对唾液分泌的影响，将Pilocarpine Hydrochloride（0.5 mg/kg）注射给给大鼠。结果：运动组大鼠的唾液分泌量显著高于对照组大鼠（P<0.01）。相反，运动组大鼠唾液中的Na+浓度显著低于对照组大鼠（P<0.05）。[1]
别名	盐酸毛果芸香碱, Pilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochloride

化学信息

储存&溶解度

存储

store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 24.5 mg/mL (100.11 mM), Sonication is recommended.

DMSO: 138 mg/mL (563.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.35 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO