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FT011 是抗纤维化剂,能够抑制胶原蛋白 I 和 III 的 mRNA 表达,减少胶原蛋白合成。
FT011 是抗纤维化剂,能够抑制胶原蛋白 I 和 III 的 mRNA 表达,减少胶原蛋白合成。


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| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 185 | 现货 | |
| 5 mg | ¥ 398 | 现货 | |
| 10 mg | ¥ 663 | 现货 | |
| 25 mg | ¥ 1,270 | 现货 | |
| 50 mg | ¥ 2,320 | 现货 | |
| 100 mg | ¥ 3,730 | 现货 | |
| 200 mg | ¥ 4,720 | 待询 | |
| 1 mL x 10 mM (in DMSO) | ¥ 455 | 现货 |
TargetMol的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
| 产品描述 | FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy. |
| 体内活性 | A direct anti-fibrotic agent, FT011, attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy[1]. |
| 动物实验 | Homozygous Ren-2 rats were randomized to receive streptozotocin or vehicle then further randomized to FT011 (200 mg/kg/day) or vehicle treatment for 6 weeks. Prior to tissue collection, cardiac function was assessed via echocardiography and cardiac catheterization. Total collagen deposition and cardiomyocyte hypertrophy were assessed by picrosirius red and haematoxylin and eosin staining, respectively. Macrophage interstitial infiltration and type I and III collagen were quantitated by immunostaining[1]. |
| 分子量 | 351.35 |
| 分子式 | C20H17NO5 |
| CAS No. | 1001288-58-9 |
| Smiles | COc1cc(\C=C\C(=O)Nc2ccccc2C(O)=O)ccc1OCC#C |
| 密度 | 1.307 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 29 mg/mL (82.54 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+90% Corn Oil: 2 mg/mL (5.69 mM), Sonication is recommended. 请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。 | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
该溶液配制表仅适用于固体产品。对于液体产品,请根据标明的浓度或密度计算稀释方案。 | |||||||||||||||||||||||||||||||
对于不同动物的给药剂量换算,您也可以参考 更多