Venadaparib hydrochloride

Name: Venadaparib hydrochloride
Brand: TargetMol
SKU: T39147
Rating: 4.5 (1 reviews)

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产品编号 T39147Cas号 1681020-60-9

别名 IDX-1197 hydrochloride

Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor that exhibits significant anticancer properties. It is particularly effective in solid tumor research.

Venadaparib hydrochloride

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产品编号 T39147 别名 IDX-1197 hydrochlorideCas号 1681020-60-9

Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor that exhibits significant anticancer properties. It is particularly effective in solid tumor research.

规格	价格	库存	数量
25 mg	¥ 10,600	1-2周

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产品描述	Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor that exhibits significant anticancer properties. It is particularly effective in solid tumor research.
靶点活性	PARP2:1 nM (IC50), PARP1:1.4 nM (IC50)
体外活性	Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC 50 values of ≤5nM and 50nM[2].
体内活性	In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1].
别名	IDX-1197 hydrochloride