TD-198946, a potent chondrogenic agent, is a thienoindazole derivative.

For intra-articular injection, TD-198946 is dissolved at 100 nM in a solution of 45% 2-hydropropyl-b-cyclodextrin in saline.Mouse: Each of the prevention and repair models had two groups: (1) TD-198946-treated animals and (2) saline-treated animals. In all the mice tested the left knee joints underwent the operation and the right knee joints are sham-operated. Mice are re-anesthetized and given a 10 μL intra-articular injection of TD-198946 or saline immediately after surgery (prevention model) or 4 weeks following surgery (repair model) every 5 days for 8 or 4 weeks, respectively.