Name: TAM-16
Brand: TargetMol
SKU: T87490
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述	TAM-16 is a potent, orally active inhibitor of polyketide synthase 13 (Pks13) with an IC50 value of 0.32 μM, demonstrating promising activity against Mycobacterium tuberculosis. Additionally, TAM-16 inhibits the hERG cardiac ion channel [1] [2].
体外活性	TAM-16 (compound 1) inhibits M. tuberculosis strain H37Rv with an IC50 value of 0.08 μM [1] and targets Pks13 to inhibit Mycobacterium tuberculosis at concentrations of 0-10 μM [1].
体内活性	在一项关于BALB/c小鼠结核病(TB)模型的研究中，TAM-16 (compound 1) 的口服处理剂量为200 mg/kg，每日一次，连续服用14天，显著减少了肺部的CFU（colony-forming units）计数，与未经治疗的对照小鼠相比，减少了约0.9 log 10 [2]。这表明TAM-16能有效预防小鼠TB感染模型中的典型肺部病变。

化学信息

分子量	380.44
分子式	C₂₂H₂₄N₂O₄
CAS No.	2030241-59-7
Smiles	C(NC)(=O)C=1C=2C(OC1C3=CC=C(O)C=C3)=CC=C(O)C2CN4CCCCC4

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

TAM-16