规格

价格

库存

数量

1 mg

¥ 178

现货

5 mg

¥ 413

现货

10 mg

¥ 588

现货

25 mg

¥ 980

现货

50 mg

¥ 1,590

现货

100 mg

¥ 2,480

现货

200 mg

¥ 3,660

现货

1 mL x 10 mM (in DMSO)

¥ 433

现货

生物活性

产品描述	Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.
靶点活性	HBV (HepG2 cells):3.75 nM(ec50)
体外活性	BMS-200475抑制HBV蛋白引物（EC50 值为 3.75 nM），抑制反转录酶的启动。与其他抗RNA和DNA病毒化合物相比，BMS-200475的抗病毒活性显著下降[1]。相对于其他脱氧鸟苷类似物（penciclovir、ganciclovir、lobucavir、aciclovir 或 lamivudine），BMS-200475更容易被磷酸化为其活性代谢物。BMS-200475 的细胞内半衰期为15小时[2]。
体内活性	BMS-200475（p.o ,剂量自0.02至0.5 mg/kg体重，连续1至3个月治疗）能有效降低慢性感染土拨鼠中的土拨鼠乙型肝炎病毒（WHV）血症水平[3]。
细胞实验	BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1].
别名	恩替卡韦, SQ34676, BMS200475

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 63.13 mg/mL (227.68 mM), Sonication is recommended.

体内实验配方

5% DMSO+95% Saline: 1 mg/mL (3.61 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO