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SGK1-IN-4

Name: SGK1-IN-4
Brand: TargetMol
SKU: T9977
Rating: 4.5 (1 reviews)

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货号 T9977Cas号 1628048-93-0

SGK1-IN-4 是 SGK1 的特异性抑制剂，可用于骨关节炎研究。

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SGK1-IN-4

一键复制产品信息

很棒

货号 T9977Cas号 1628048-93-0

SGK1-IN-4 是 SGK1 的特异性抑制剂，可用于骨关节炎研究。

规格	价格	库存
1 mg	¥ 1,230	待询
5 mg	¥ 2,820	待询
10 mg	¥ 3,970	待询
25 mg	¥ 6,380	待询
50 mg	¥ 8,590	待询
100 mg	¥ 11,600	待询
200 mg	¥ 15,600	待询
1 mL x 10 mM (in DMSO)	¥ 3,190	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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产品操作手册

产品介绍

SGK1-IN-4 AI Summary

SGK1-IN-4 demonstrates a potent inhibitory effect on SGK1, evidenced by an IC50 value of less than 1.5 nM in a substrate phosphorylation assay and 120.0 nM in a cellular activity assay. Beyond its strong inhibition of recombinant human SGK1, with IC50 values below 1.0 nM, it also inhibits mouse and rat SGK1 with IC50 values of 253.0 nM and 358.0 nM, respectively. The compound has a distribution coefficient (LogD) of 2.8 and shows 57.0% inhibition of RSK1 kinase at 0.1 µM concentration. It exhibits metabolic stability in mouse and rat liver microsomes, with drug degradation rates of 6.0% and 7.0%, respectively, and high chemical stability with moderate metabolic degradation in human liver microsomes. The IC50 for CYP3A4 inhibition in human liver microsomes using testosterone as a substrate exceeds 3000.0 nM, although it shows weak inhibition when midazolam is the substrate. SGK1-IN-4 is highly permeable in human Caco2 cells and has aqueous solubility at pH 7.4. Additionally, it inhibits chondrocyte hypertrophic differentiation in mouse ATDC-5 cells with an IC50 of 50.0 nM and exhibits variable inhibition of human ERG at different concentrations. Overall, SGK1-IN-4 displays a diverse pharmacological profile, encompassing significant enzyme inhibition, favorable metabolic stability, good permeability, and inhibition of specific cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.

化学信息

分子量	517.96
分子式	C₂₃H₂₁ClFN₅O₄S
CAS No.	1628048-93-0
Smiles	O[C@H]1CC[C@@H](CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 245 mg/mL (473.01 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9307 mL	9.6533 mL	19.3065 mL	96.5326 mL
5 mM	0.3861 mL	1.9307 mL	3.8613 mL	19.3065 mL
10 mM	0.1931 mL	0.9653 mL	1.9307 mL	9.6533 mL
20 mM	0.0965 mL	0.4827 mL	0.9653 mL	4.8266 mL
50 mM	0.0386 mL	0.1931 mL	0.3861 mL	1.9307 mL
100 mM	0.0193 mL	0.0965 mL	0.1931 mL	0.9653 mL

计算器

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稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。