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2'-Deoxy-2'-fluorouridine

Name: 2'-Deoxy-2'-fluorouridine
Brand: TargetMol
SKU: T38239
Price: 111 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T38239Cas号 784-71-4

别名 2'-氟-2'-脱氧尿苷

2'-Deoxy-2'-fluorouridine 是合成抗流感病毒试剂的中间体。

为众多的药物研发团队赋能，

让新药发现更简单！

2'-Deoxy-2'-fluorouridine

一键复制产品信息

很棒

纯度: 99.93%

货号 T38239 别名 2'-氟-2'-脱氧尿苷Cas号 784-71-4

2'-Deoxy-2'-fluorouridine 是合成抗流感病毒试剂的中间体。

规格	价格	库存
200 mg	¥ 111	现货
500 mg	¥ 175	现货
1 g	¥ 251	待询
2 g	¥ 358	待询
1 mL x 10 mM (in DMSO)	¥ 120	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

2'-Deoxy-2'-fluorouridine AI Summary

2'-Deoxy-2'-fluorouridine exhibits a broad spectrum of bioactivities including antiviral, antiherpetic, and antiproliferative properties across various cell types. It inhibits the influx competition with [6-3H]thymidine in mouse erythrocytes with a Ki of 120,000 nM. The compound demonstrates significant antiherpetic activity against HSV-1 (ED50 of 0.8 µM) and HSV-2 (ED50 of 6.0 µM), while inhibiting the growth of normal human lymphocytic cells with an ID50 greater than 100 µM. Additionally, 2'-Deoxy-2'-fluorouridine shows growth inhibition against a range of human tumor cell lines, including renal, breast, non-small cell lung, leukemia, ovarian, melanoma, central nervous system, prostate, and colon cells, with GI50 values spanning from nanomolar to micromolar concentrations, indicating its potency in cancer cell line inhibition. The compound also acts as an inhibitor of HCV 1b NS5b polymerase with an IC50 of 12,800 nM and demonstrates antiviral properties against RSV A2 by targeting RSV A2 RNA-dependent RNA polymerase in human Hep2 cells. Moreover, it shows inhibitory effects on human mitochondrial RNA polymerase and the mitochondrial DNA polymerase gamma complex..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].
别名	2'-氟-2'-脱氧尿苷

化学信息

分子量	246.19
分子式	C₉H₁₁FN₂O₅
CAS No.	784-71-4
Smiles	OC[C@H]1O[C@H]([C@H](F)[C@@H]1O)n1ccc(=O)[nH]c1=O
密度	1.63 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (406.19 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.25 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0619 mL	20.3095 mL	40.6190 mL	203.0952 mL
5 mM	0.8124 mL	4.0619 mL	8.1238 mL	40.6190 mL
10 mM	0.4062 mL	2.0310 mL	4.0619 mL	20.3095 mL
20 mM	0.2031 mL	1.0155 mL	2.0310 mL	10.1548 mL
50 mM	0.0812 mL	0.4062 mL	0.8124 mL	4.0619 mL
100 mM	0.0406 mL	0.2031 mL	0.4062 mL	2.0310 mL