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NKL 22

Name: NKL 22
Brand: TargetMol
SKU: T3206
Price: 115 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 96.24%

货号 T3206Cas号 537034-15-4

别名 PAOA, Histone Deacetylase Inhibitor IV

NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂，对 HDAC2/4/5/7/8 具有选择性，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。

为众多的药物研发团队赋能，

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NKL 22

一键复制产品信息

很棒

纯度: 96.24%

货号 T3206 别名 PAOA, Histone Deacetylase Inhibitor IVCas号 537034-15-4

规格	价格	库存
2 mg	¥ 115	现货
5 mg	¥ 176	现货
10 mg	¥ 297	现货
25 mg	¥ 592	现货
50 mg	¥ 942	现货
100 mg	¥ 1,480	现货
200 mg	¥ 2,190	现货
1 mL x 10 mM (in DMSO)	¥ 197	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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纯度: 96.24%

颜色: 白色

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COA HNMR LCMS 产品操作手册

产品介绍

NKL 22 AI Summary

NKL 22 exhibits significant bioactivity as a histone deacetylase (HDAC) inhibitor, particularly potent against HDAC1 and HDAC3/NCOR2 with IC50 values of 199.0 nM and 69.0 nM, respectively. It also shows moderate activity against HDAC2 (IC50 = 1590.0 nM) and HDAC8 (IC50 = 5000.0 nM), but negligible activity against HDAC4, HDAC5, HDAC7, and HDAC8 (IC50 > 180,000.0 nM). In U937 cells, NKL 22 inhibits HDAC1 by 28.9% at 5 µM without affecting HDAC4 and induces granulocytic differentiation as evidenced by an 18.3% increase in CD11c expression after 30 hours at the same concentration. Additionally, the compound enhances FXN mRNA expression and frataxin protein levels in lymphocytes from Friedreich's ataxia patients and exhibits inhibition of HDACs in HeLa cell extracts. For its antiviral properties, NKL 22 inhibits SARS-CoV-2 3CL-Pro protease by 9.33% at 20 µM and demonstrates modest antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM with an inhibition rate of 0.26%. Furthermore, NKL 22 shows cytotoxic activity against human HepG2 cells with an IC50 of 11700.0 nM, indicating its potential as a cytotoxic agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
靶点活性	HDAC8:5 μM (IC50), HDAC1:0.199 μM (IC50), HDAC3:0.069 μM (IC50), HDAC2:1.59 μM (IC50)
别名	PAOA, Histone Deacetylase Inhibitor IV

化学信息

分子量	325.4
分子式	C₁₉H₂₃N₃O₂
CAS No.	537034-15-4
Smiles	Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1
密度	1.213g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (153.66 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0731 mL	15.3657 mL	30.7314 mL	153.6570 mL
5 mM	0.6146 mL	3.0731 mL	6.1463 mL	30.7314 mL
10 mM	0.3073 mL	1.5366 mL	3.0731 mL	15.3657 mL
20 mM	0.1537 mL	0.7683 mL	1.5366 mL	7.6829 mL
50 mM	0.0615 mL	0.3073 mL	0.6146 mL	3.0731 mL
100 mM	0.0307 mL	0.1537 mL	0.3073 mL	1.5366 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。