LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.

LCB 03-0110处理TGF-β1和I型胶原暴露的细胞时，特别显著地抑制了酪氨酸861的磷酸化，1μM浓度下可使其降低约50%，而3μM浓度几乎完全抑制。